| Literature DB >> 23672573 |
Catherine A Campos1, Joseph B Gianino, Brandon L Ashfeld.
Abstract
Herein is described a titanium-catalyzed three-component coupling to assemble β-alkynyl ketones in a single operation. Treatment of an aryl aldehyde with an acetylide and silyl enol ether in the presence of a bifunctional titanocene catalyst enables the highly convergent assembly of β-alkynyl ketones in good to excellent yields.Entities:
Year: 2013 PMID： 23672573 DOI： 10.1021/ol400943a
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005