| Literature DB >> 23671085 |
Sang-Wook Park1, Wei Li, Andrea Viehhauser, Bin He, Soonok Kim, Anders K Nilsson, Mats X Andersson, Joshua D Kittle, Madana M R Ambavaram, Sheng Luan, Alan R Esker, Dorothea Tholl, Daniela Cimini, Mats Ellerström, Gitta Coaker, Thomas K Mitchell, Andy Pereira, Karl-Josef Dietz, Christopher B Lawrence.
Abstract
The jasmonate family of phytohormones plays central roles in plant development and stress acclimation. However, the architecture of their signaling circuits remains largely unknown. Here we describe a jasmonate family binding protein, cyclophilin 20-3 (CYP20-3), which regulates stress-responsive cellular redox homeostasis. (+)-12-Oxo-phytodienoic acid (OPDA) binding promotes CYP20-3 to form a complex with serine acetyltransferase 1, which triggers the formation of a hetero-oligomeric cysteine synthase complex with O-acetylserine(thiol)lyase B in chloroplasts. The cysteine synthase complex formation then activates sulfur assimilation that leads to increased levels of thiol metabolites and the buildup of cellular reduction potential. The enhanced redox capacity in turn coordinates the expression of a subset of OPDA-responsive genes. Thus, we conclude that CYP20-3 is a key effector protein that links OPDA signaling to amino acid biosynthesis and cellular redox homeostasis in stress responses.Entities:
Keywords: GSH; TGA; cysteine biosynthesis; plant plasticity; wounding
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Year: 2013 PMID： 23671085 PMCID： PMC3677464 DOI： 10.1073/pnas.1218872110
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205