Literature DB >> 23670197

Between new genetic discoveries and large randomized trials--neurological research in the era of systems medicine.

Thomas Misgeld1, Stefan F Lichtenthaler, Martin Dichgans.   

Abstract

The 2012 Eibsee meeting on 'Cellular Mechanisms of Neurodegeneration' addressed the need to integrate research on classical neurodegenerative mechanisms with investigations that relate to the immunological, glial and vascular sequels that accompany and often propagate neuronal injury. We report on the central topics that were addressed and discuss future directions towards establishing 'systems neurology' as a new integrated research field.

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Mesh：

Year:  2013        PMID： 23670197      PMCID： PMC3674454          DOI： 10.1038/embor.2013.70

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


  26 in total

Review 1.  Advances in understanding the molecular basis of frontotemporal dementia.

Authors:  Rosa Rademakers; Manuela Neumann; Ian R Mackenzie
Journal:  Nat Rev Neurol       Date:  2012-06-26       Impact factor: 42.937

2.  Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons.

Authors:  Peer-Hendrik Kuhn; Katarzyna Koroniak; Sebastian Hogl; Alessio Colombo; Ulrike Zeitschel; Michael Willem; Christiane Volbracht; Ute Schepers; Axel Imhof; Albrecht Hoffmeister; Christian Haass; Steffen Roßner; Stefan Bräse; Stefan F Lichtenthaler
Journal:  EMBO J       Date:  2012-06-22       Impact factor: 11.598

3.  Alzheimer's research. Stopping Alzheimer's before it starts.

Authors:  Greg Miller
Journal:  Science       Date:  2012-08-17       Impact factor: 47.728

4.  A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.

Authors:  Thorlakur Jonsson; Jasvinder K Atwal; Stacy Steinberg; Jon Snaedal; Palmi V Jonsson; Sigurbjorn Bjornsson; Hreinn Stefansson; Patrick Sulem; Daniel Gudbjartsson; Janice Maloney; Kwame Hoyte; Amy Gustafson; Yichin Liu; Yanmei Lu; Tushar Bhangale; Robert R Graham; Johanna Huttenlocher; Gyda Bjornsdottir; Ole A Andreassen; Erik G Jönsson; Aarno Palotie; Timothy W Behrens; Olafur T Magnusson; Augustine Kong; Unnur Thorsteinsdottir; Ryan J Watts; Kari Stefansson
Journal:  Nature       Date:  2012-08-02       Impact factor: 49.962

5.  Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis.

Authors:  Petar Marinkovic; Miriam S Reuter; Monika S Brill; Leanne Godinho; Martin Kerschensteiner; Thomas Misgeld
Journal:  Proc Natl Acad Sci U S A       Date:  2012-02-27       Impact factor: 11.205

6.  Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs.

Authors:  Clotilde Lagier-Tourenne; Magdalini Polymenidou; Kasey R Hutt; Anthony Q Vu; Michael Baughn; Stephanie C Huelga; Kevin M Clutario; Shuo-Chien Ling; Tiffany Y Liang; Curt Mazur; Edward Wancewicz; Aneeza S Kim; Andy Watt; Sue Freier; Geoffrey G Hicks; John Paul Donohue; Lily Shiue; C Frank Bennett; John Ravits; Don W Cleveland; Gene W Yeo
Journal:  Nat Neurosci       Date:  2012-09-30       Impact factor: 24.884

7.  Loss of fused in sarcoma (FUS) promotes pathological Tau splicing.

Authors:  Denise Orozco; Sabina Tahirovic; Kristin Rentzsch; Benjamin M Schwenk; Christian Haass; Dieter Edbauer
Journal:  EMBO Rep       Date:  2012-06-19       Impact factor: 8.807

8.  Purified and synthetic Alzheimer's amyloid beta (Aβ) prions.

Authors:  Jan Stöhr; Joel C Watts; Zachary L Mensinger; Abby Oehler; Sunny K Grillo; Stephen J DeArmond; Stanley B Prusiner; Kurt Giles
Journal:  Proc Natl Acad Sci U S A       Date:  2012-06-18       Impact factor: 11.205

9.  Mitochondrial DNA polymorphisms specifically modify cerebral β-amyloid proteostasis.

Authors:  Katja Scheffler; Markus Krohn; Tina Dunkelmann; Jan Stenzel; Bruno Miroux; Saleh Ibrahim; Oliver von Bohlen Und Halbach; Hans-Jochen Heinze; Lary C Walker; Jörg A Gsponer; Jens Pahnke
Journal:  Acta Neuropathol       Date:  2012-04-18       Impact factor: 17.088

10.  ABC transporters B1, C1 and G2 differentially regulate neuroregeneration in mice.

Authors:  Toni Schumacher; Markus Krohn; Jacqueline Hofrichter; Cathleen Lange; Jan Stenzel; Johannes Steffen; Tina Dunkelmann; Kristin Paarmann; Christina Fröhlich; Annekathrin Uecker; Anne-Sophie Plath; Alexandra Sommer; Thomas Brüning; Hans-Jochen Heinze; Jens Pahnke
Journal:  PLoS One       Date:  2012-04-24       Impact factor: 3.240
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