| Literature DB >> 23669867 |
Sasan Andalib1, Mahnaz Talebi, Ebrahim Sakhinia, Mehdi Farhoudi, Homayoun Sadeghi-Bazargani, Azadeh Motavallian, Yones Pilehvar-Soltanahmadi.
Abstract
Multiple sclerosis (MS) is a debilitating disease of the central nervous system. Its etiology is still an unanswered enigma; its symptoms are varied and unpredictable; and there is no cure for it. Genetics has been introduced as a contributing factor to MS. Not only may MS stem from nuclear gene variations/mutations, but also it may arise from mitochondrial gene variations/mutations. The association of mitochondrial DNA variations/mutations with the pathogenesis of MS has, so far, been analyzed by several studies. This paper reviews the literature with regard to MS and corresponding mitochondrial DNA variations.Entities:
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Year: 2013 PMID： 23669867 DOI： 10.1016/j.jns.2013.04.018
Source DB: PubMed Journal: J Neurol Sci ISSN： 0022-510X Impact factor: 3.181