| Literature DB >> 23669283 |
Abstract
Natural killer T cells (NKT) are innate-like cells which are abundant in liver sinusoids and express the cell surface receptors of NK cells (e.g., NK1.1 (mouse) or CD161+/CD56+(human)) as well as an antigen receptor (TCR) characteristic of conventional T cells. NKT cells recognize lipid antigens in the context of CD1d, a non-polymorphic MHC class I-like molecule. Activation of NKT cells has a profound influence on the immune response against tumors and infectious organisms and in autoimmune diseases. NKT cells can be categorized into at least two distinct subsets: iNKT or type I use a semi-invariant TCR, whereas type II NKT TCRs are more diverse. Recent evidence suggests that NKT-cell subsets can play opposing roles early in non-microbial liver inflammation in that type I NKT are proinflammatory whereas type II NKT cells inhibit type I NKT-mediated liver injury.Entities:
Keywords: ALD; ConA; DC; Hepatitis; IRI; Inflammation; KC; Kupffer cells; MCD; MHC; NAFLD; NK; NKT; NKT cells; OPN; SCD; Sulfatide; T cell receptor; TAA; TCR; alcoholic liver disease; concavalin A; dendritic cells; ischemic reperfusion injury; major histocompatibility complex; methionine choline deficient diet; natural killer T cells; natural killer cells; non-alcoholic fatty liver disease; osteopontin; sickle cell disease; thioacetamide; α-galactosylceramide; αGalCer
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Year: 2013 PMID： 23669283 PMCID： PMC4086465 DOI： 10.1016/j.jhep.2013.02.032
Source DB: PubMed Journal: J Hepatol ISSN： 0168-8278 Impact factor: 25.083