| Literature DB >> 23668989 |
Réjean Ruel1, Alexandre L'Heureux, Carl Thibeault, Jean-Paul Daris, Alain Martel, Laura A Price, Qimin Wu, Ji Hua, Ruth R Wexler, Robert Rehfuss, Patrick Y S Lam.
Abstract
Five-membered-ring heterocyclic urea mimics have been found to be potent and selective antagonists of the P2Y1 receptor. SAR of the various heterocyclic replacements is presented, as well as side-chain SAR of the more potent thiadiazole ring system which leads to thiadiazole 4c as a new antiplatelet agent.Entities:
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Year: 2013 PMID： 23668989 DOI： 10.1016/j.bmcl.2013.04.041
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823