Literature DB >> 2366822

Single-fiber electromyography in experimental autoimmune myasthenia gravis.

J J Verschuuren1, F Spaans, M H De Baets.   

Abstract

The sensitivity of stimulated single-fiber electromyography in the detection of early abnormalities in neuromuscular transmission in experimental autoimmune myasthenia gravis (EAMG) was tested. Increased jitter and blocking were seen up to 3 weeks before clinical illness or decrement developed. Stimulation at 10 Hz appeared more sensitive in detection of abnormalities than stimulation at 3 or 5 Hz. Jitter values did not correlate with anti-Torpedo acetylcholine receptor (AChR), nor with anti-rat AChR antibody titer. No correlation was found between jitter and AChR loss or AChR-antibody complexes in muscle. It is concluded that, in addition to AChR loss and the presence of AChR-antibody complexes, other factors must determine the neuromuscular dysfunction in EAMG and possibly myasthenia gravis.

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Year:  1990        PMID： 2366822     DOI： 10.1002/mus.880130604

Source DB:  PubMed          Journal:  Muscle Nerve        ISSN： 0148-639X            Impact factor:   3.217


  6 in total

1.  Overexpression of rapsyn in rat muscle increases acetylcholine receptor levels in chronic experimental autoimmune myasthenia gravis.

Authors:  Pilar Martínez-Martínez; Mario Losen; Hans Duimel; Peter Frederik; Frank Spaans; Peter Molenaar; Angela Vincent; Marc H De Baets
Journal:  Am J Pathol       Date:  2007-02       Impact factor: 4.307

Review 2.  Myasthenia gravis: an autoimmune response against the acetylcholine receptor.

Authors:  Y M Graus; M H De Baets
Journal:  Immunol Res       Date:  1993       Impact factor: 2.829

3.  Guidelines for pre-clinical assessment of the acetylcholine receptor--specific passive transfer myasthenia gravis model-Recommendations for methods and experimental designs.

Authors:  Linda L Kusner; Mario Losen; Angela Vincent; Jon Lindstrom; Socrates Tzartos; Konstantinos Lazaridis; Pilar Martinez-Martinez
Journal:  Exp Neurol       Date:  2015-03-03       Impact factor: 5.330

4.  Impaired neuromuscular transmission and skeletal muscle fiber necrosis in mice lacking Na/Ca exchanger 3.

Authors:  Sophie Sokolow; Mario Manto; Philippe Gailly; Jordi Molgó; Clarisse Vandebrouck; Jean-Marie Vanderwinden; Andre Herchuelz; Stéphane Schurmans
Journal:  J Clin Invest       Date:  2004-01       Impact factor: 14.808

5.  Standardization of the experimental autoimmune myasthenia gravis (EAMG) model by immunization of rats with Torpedo californica acetylcholine receptors--Recommendations for methods and experimental designs.

Authors:  Mario Losen; Pilar Martinez-Martinez; Peter C Molenaar; Konstantinos Lazaridis; Socrates Tzartos; Talma Brenner; Rui-Sheng Duan; Jie Luo; Jon Lindstrom; Linda Kusner
Journal:  Exp Neurol       Date:  2015-03-18       Impact factor: 5.330

6.  A Recombinant Acetylcholine Receptor α1 Subunit Extracellular Domain Is a Promising New Drug Candidate for Treatment Of Myasthenia Gravis.

Authors:  Konstantinos Lazaridis; Maria Fernandez-Santoscoy; Vasiliki Baltatzidou; Jan-Olof Andersson; Richard Christison; John Grünberg; Socrates Tzartos; Björn Löwenadler; Charlotte Fribert
Journal:  Front Immunol       Date:  2022-06-03       Impact factor: 8.786
  6 in total

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