Literature DB >> 23667410

Helicobacter pylori and Gastric Inflammation: Role of MUC1 Mucin.

Erik P Lillehoj1, Wei Guang, Hua Ding, Steven J Czinn, Thomas G Blanchard.   

Abstract

More than half of the world's population is infected with Helicobacter pylori, which is strongly linked to the development of chronic gastric inflammation (gastritis), peptic ulcer disease, and stomach cancer. However, for unknown reasons, the vast majority of infected individuals are asymptomatic beyond histologic inflammation. This review article will summarize current knowledge on the molecular mechanisms of H. pylori colonization of the gastric mucosa, with a particular focus on the biochemistry of MUC1 mucin in the host response to bacterial infection.

Entities:  

Keywords:  Helicobacter pylori; MUC1 mucin; epithelium; stomach

Year:  2012        PMID： 23667410      PMCID： PMC3648873          DOI： 10.3233/JPB-2012-00058

Source DB:  PubMed          Journal:  J Pediatr Biochem        ISSN： 1879-5390


  59 in total

1.  Involvement of the MAP kinase ERK2 in MUC1 mucin signaling.

Authors:  D Meerzaman; P S Shapiro; K C Kim
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2001-07       Impact factor: 5.464

Review 2.  Respiratory tract mucin genes and mucin glycoproteins in health and disease.

Authors:  Mary Callaghan Rose; Judith A Voynow
Journal:  Physiol Rev       Date:  2006-01       Impact factor: 37.312

3.  Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells.

Authors:  N Murata-Kamiya; Y Kurashima; Y Teishikata; Y Yamahashi; Y Saito; H Higashi; H Aburatani; T Akiyama; R M Peek; T Azuma; M Hatakeyama
Journal:  Oncogene       Date:  2007-01-22       Impact factor: 9.867

Review 4.  Oncogenic mechanisms of the Helicobacter pylori CagA protein.

Authors:  Masanori Hatakeyama
Journal:  Nat Rev Cancer       Date:  2004-09       Impact factor: 60.716

5.  Biochemical interactions among intercellular adhesion molecules expressed by airway epithelial cells.

Authors:  Keena E Molock; Erik P Lillehoj
Journal:  Biochem Biophys Res Commun       Date:  2006-03-10       Impact factor: 3.575

6.  DF3/MUC1 signaling in multiple myeloma cells is regulated by interleukin-7.

Authors:  Yongqing Li; Wen Chen; Jian Ren; Wei-Hsuan Yu; Quan Li; Kiyotsugu Yoshida; Donald Kufe
Journal:  Cancer Biol Ther       Date:  2003 Mar-Apr       Impact factor: 4.742

7.  Pseudomonas aeruginosa stimulates phosphorylation of the airway epithelial membrane glycoprotein Muc1 and activates MAP kinase.

Authors:  Erik P Lillehoj; Hakryul Kim; Ellen Y Chun; K Chul Kim
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2004-06-25       Impact factor: 5.464

Review 8.  Role of type IV secretion in Helicobacter pylori pathogenesis.

Authors:  Steffen Backert; Matthias Selbach
Journal:  Cell Microbiol       Date:  2008-04-08       Impact factor: 3.715

9.  Age at acquisition of Helicobacter pylori infection: comparison of a high and a low prevalence country.

Authors:  P Lindkvist; D Asrat; I Nilsson; E Tsega; G L Olsson; B Wretlind; J Giesecke
Journal:  Scand J Infect Dis       Date:  1996

10.  MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy.

Authors:  Sara K Lindén; Yong H Sheng; Alison L Every; Kim M Miles; Emma C Skoog; Timothy H J Florin; Philip Sutton; Michael A McGuckin
Journal:  PLoS Pathog       Date:  2009-10-09       Impact factor: 6.823
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  1 in total

1.  Mammalian Neuraminidases in Immune-Mediated Diseases: Mucins and Beyond.

Authors:  Erik P Lillehoj; Irina G Luzina; Sergei P Atamas
Journal:  Front Immunol       Date:  2022-04-11       Impact factor: 8.786
  1 in total

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