Literature DB >> 23666496

Dabigatran-associated subdural hemorrhage: using thromboelastography (TEG(®)) to guide decision-making.

Ron Neyens1, Nicole Bohm, Madelyne Cearley, Charles Andrews, Julio Chalela.   

Abstract

Novel oral anticoagulants present challenges and uncertainties in the management of hemorrhagic emergencies. An 84-year-old man taking dabigatran presented with a subdural hematoma requiring neurosurgical intervention. Routine coagulation assays were prolonged at admission and following administration of Factor VIII Inhibitor Bypassing Activity (FEIBA). Thromboelastography (TEG(®)) was utilized to assess clot dynamics prior to placement of a subdural drain, which was safely inserted despite a prolonged thrombin time (TT). Exclusive reliance on the TT may delay necessary interventions. TEG(®) may be a valuable tool to investigate hemostasis in patients on dabigatran requiring emergent procedures.

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Year:  2014        PMID: 23666496     DOI: 10.1007/s11239-013-0933-9

Source DB:  PubMed          Journal:  J Thromb Thrombolysis        ISSN: 0929-5305            Impact factor:   2.300


  11 in total

1.  Acutely injured patients on dabigatran.

Authors:  Bryan A Cotton; James J McCarthy; John B Holcomb
Journal:  N Engl J Med       Date:  2011-11-24       Impact factor: 91.245

Review 2.  Critical factors contributing to the thromboelastography trace.

Authors:  Stephen G MacDonald; Roger J Luddington
Journal:  Semin Thromb Hemost       Date:  2010-10-26       Impact factor: 4.180

3.  Argatroban "reversal" is caused by nonphysiologic stimulation of coagulation, not activated factor VII.

Authors:  Kenichi A Tanaka; Fania Szlam; Kaoru Koyama; Jerrold H Levy
Journal:  J Cardiothorac Vasc Anesth       Date:  2010-01-06       Impact factor: 2.628

4.  Pressure changes within a chronic subdural hematoma during hemodialysis.

Authors:  T A Kopitnik; R de Andrade; M A Gold; G R Nugent
Journal:  Surg Neurol       Date:  1989-10

5.  Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: a randomised crossover ex vivo study in healthy volunteers.

Authors:  Raphael Marlu; Enkelejda Hodaj; Adeline Paris; Pierre Albaladejo; Jean Luc Cracowski; Jean Luc Crackowski; Gilles Pernod
Journal:  Thromb Haemost       Date:  2012-05-25       Impact factor: 5.249

Review 6.  Dabigatran etexilate--a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity.

Authors:  Joanne van Ryn; Joachim Stangier; Sebastian Haertter; Karl-Heinz Liesenfeld; Wolfgang Wienen; Martin Feuring; Andreas Clemens
Journal:  Thromb Haemost       Date:  2010-03-29       Impact factor: 5.249

7.  Impact of dabigatran on a large panel of routine or specific coagulation assays. Laboratory recommendations for monitoring of dabigatran etexilate.

Authors:  Jonathan Douxfils; François Mullier; Séverine Robert; Christian Chatelain; Bernard Chatelain; Jean-Michel Dogné
Journal:  Thromb Haemost       Date:  2012-03-22       Impact factor: 5.249

8.  Thrombin-activated thrombelastography for evaluation of thrombin interaction with thrombin inhibitors.

Authors:  Taro Taketomi; Fania Szlam; Jakob Vinten-Johansen; Jerrold H Levy; Kenichi A Tanaka
Journal:  Blood Coagul Fibrinolysis       Date:  2007-12       Impact factor: 1.276

9.  An evaluation of monitoring possibilities of argatroban using rotational thromboelastometry and activated partial thromboplastin time.

Authors:  M Engström; M Rundgren; U Schött
Journal:  Acta Anaesthesiol Scand       Date:  2009-08-31       Impact factor: 2.105

10.  Differential profiles of thrombin inhibitors (heparin, hirudin, bivalirudin, and dabigatran) in the thrombin generation assay and thromboelastography in vitro.

Authors:  Yiming Xu; Weizhen Wu; Liangsu Wang; Madhu Chintala; Andrew S Plump; Martin L Ogletree; Zhu Chen
Journal:  Blood Coagul Fibrinolysis       Date:  2013-04       Impact factor: 1.276

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  10 in total

Review 1.  The impact of prothrombin complex concentrates when treating DOAC-associated bleeding: a review.

Authors:  Maureane Hoffman; Joshua N Goldstein; Jerrold H Levy
Journal:  Int J Emerg Med       Date:  2018-12-03

Review 2.  Dabigatran-Associated Intracranial Hemorrhage: Literature Review and Institutional Experience.

Authors:  Amber E King; Dorota K Szarlej; Fred Rincon
Journal:  Neurohospitalist       Date:  2015-10

Review 3.  [Hemorrhage under direct oral anticoagulants : Occurrence and treatment in intensive care patients].

Authors:  H M Hoffmeister; H Darius; M Buerke
Journal:  Med Klin Intensivmed Notfmed       Date:  2018-05-04       Impact factor: 0.840

4.  Effects of non-vitamin K antagonist oral anticoagulants on fibrin clot and whole blood clot formation, integrity and thrombolysis in patients with atrial fibrillation.

Authors:  Yee Cheng Lau; Qinmei Xiong; Eduard Shantsila; Gregory Y H Lip; Andrew D Blann
Journal:  J Thromb Thrombolysis       Date:  2016-11       Impact factor: 2.300

Review 5.  Targeted Thromboelastographic (TEG) Blood Component and Pharmacologic Hemostatic Therapy in Traumatic and Acquired Coagulopathy.

Authors:  Mark Walsh; Stephanie Fritz; Daniel Hake; Michael Son; Sarah Greve; Manar Jbara; Swetha Chitta; Braxton Fritz; Adam Miller; Mary K Bader; Jonathon McCollester; Sophia Binz; Alyson Liew-Spilger; Scott Thomas; Anton Crepinsek; Faisal Shariff; Victoria Ploplis; Francis J Castellino
Journal:  Curr Drug Targets       Date:  2016       Impact factor: 3.465

6.  In vitro investigation of the effects of exogenous sugammadex on coagulation in orthopedic surgical patients.

Authors:  Il Ok Lee; Young Sung Kim; Hae Wone Chang; Heezoo Kim; Byung Gun Lim; Mido Lee
Journal:  BMC Anesthesiol       Date:  2018-05-24       Impact factor: 2.217

Review 7.  A Review of the Incidence Diagnosis and Treatment of Spontaneous Hemorrhage in Patients Treated with Direct Oral Anticoagulants.

Authors:  Kulothungan Gunasekaran; Venkat Rajasurya; Joe Devasahayam; Mandeep Singh Rahi; Arul Chandran; Kalaimani Elango; Goutham Talari
Journal:  J Clin Med       Date:  2020-09-15       Impact factor: 4.241

Review 8.  Monitoring of hematological and hemostatic parameters in neurocritical care patients.

Authors:  Andrew M Naidech; Monisha A Kumar
Journal:  Neurocrit Care       Date:  2014-12       Impact factor: 3.210

Review 9.  Management of anticoagulant-related intracranial hemorrhage: an evidence-based review.

Authors:  Bappaditya Ray; Salah G Keyrouz
Journal:  Crit Care       Date:  2014-05-23       Impact factor: 9.097

10.  Laboratory assessment of anti-thrombotic therapy in heart failure, atrial fibrillation and coronary artery disease: insights using thrombelastography and a micro-titre plate assay of thrombogenesis and fibrinolysis.

Authors:  Y C Lau; Q Xiong; P Ranjit; G Y H Lip; A D Blann
Journal:  J Thromb Thrombolysis       Date:  2016-08       Impact factor: 2.300

  10 in total

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