| Literature DB >> 23664888 |
Eva Vacas1, M Isabel Arenas, Laura Muñoz-Moreno, Ana M Bajo, Manuel Sánchez-Chapado, Juan C Prieto, María J Carmena.
Abstract
We studied antitumor effect of VIP in human renal cell carcinoma (RCC) (A498 cells xenografted in immunosuppressed mice). VIP-treated cells gave resulted in p53 upregulation and decreased nuclear β-catenin translocation and NFκB expression, MMP-2 and MMP-9 activities, VEGF levels and CD-34 expression. VIP led to a more differentiated tubular organization in tumours and less metastatic areas. Thus, VIP inhibits growth of A498-cell tumours acting on the major issues involved in RCC progression such as cell proliferation, microenvironment remodelling, tumour invasion, angiogenesis and metastatic ability. These antitumoral effects of VIP offer new therapeutical possibilities in RCC treatment.Entities:
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Year: 2013 PMID： 23664888 DOI： 10.1016/j.canlet.2013.04.033
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679