Literature DB >> 23664694

The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas.

Marco Locatelli1, Stefano Ferrero, Filippo Martinelli Boneschi, Leonardo Boiocchi, Mario Zavanone, Sergio Maria Gaini, Lorenzo Bello, Sonia Valentino, Elisa Barbati, Manuela Nebuloni, Alberto Mantovani, Cecilia Garlanda.   

Abstract

Inflammation is a component of glioma microenvironment. PTX3 is a component of the humoral arm of innate immunity and a candidate marker of inflammation. In the present study we assessed the expression of PTX3 in gliomas by immunohistochemistry. PTX3 expression differed across low and high-grade tumors based on histopathological diagnosis and clinical severity, positively correlating with tumor grade and severity. In a multivariate logistic regression model, only the PTX3 score was significantly associated with the presence of a high-grade tumor. Thus, PTX3 may represent a new marker of cancer-related inflammation and glioma malignancy.
Copyright © 2013 Elsevier B.V. All rights reserved.

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Year:  2013        PMID： 23664694     DOI： 10.1016/j.jneuroim.2013.04.009

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  44 in total

1.  Inhibition of pentraxin 3 in glioma cells impairs proliferation and invasion in vitro and in vivo.

Authors:  Jai-Nien Tung; Chung-Po Ko; Shun-Fa Yang; Chun-Wen Cheng; Pei-Ni Chen; Chia-Yu Chang; Chia-Liang Lin; Te-Fang Yang; Yi-Hsien Hsieh; Kun-Chung Chen
Journal:  J Neurooncol       Date:  2016-06-09       Impact factor: 4.130

2.  Proteomic Analysis of MYB-Regulated Secretome Identifies Functional Pathways and Biomarkers: Potential Pathobiological and Clinical Implications.

Authors:  Haseeb Zubair; Girijesh Kumar Patel; Mohammad Aslam Khan; Shafquat Azim; Asif Zubair; Seema Singh; Sanjeev Kumar Srivastava; Ajay Pratap Singh
Journal:  J Proteome Res       Date:  2020-01-27       Impact factor: 4.466

3.  A comprehensive analysis of candidate genes and pathways in pancreatic cancer.

Authors:  Jie Liu; Jun Li; Hali Li; Aidong Li; Biou Liu; Liou Han
Journal:  Tumour Biol       Date:  2014-11-20

4.  Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner.

Authors:  Sung-Hak Kim; Ravesanker Ezhilarasan; Emma Phillips; Daniel Gallego-Perez; Amanda Sparks; David Taylor; Katherine Ladner; Takuya Furuta; Hemragul Sabit; Rishi Chhipa; Ju Hwan Cho; Ahmed Mohyeldin; Samuel Beck; Kazuhiko Kurozumi; Toshihiko Kuroiwa; Ryoichi Iwata; Akio Asai; Jonghwan Kim; Erik P Sulman; Shi-Yuan Cheng; L James Lee; Mitsutoshi Nakada; Denis Guttridge; Biplab DasGupta; Violaine Goidts; Krishna P Bhat; Ichiro Nakano
Journal:  Cancer Cell       Date:  2016-02-08       Impact factor: 31.743

5.  Cell-autonomous and cell non-autonomous downregulation of tumor suppressor DAB2IP by microRNA-149-3p promotes aggressiveness of cancer cells.

Authors:  Arianna Bellazzo; Giulio Di Minin; Elena Valentino; Daria Sicari; Denis Torre; Luigi Marchionni; Federica Serpi; Michael B Stadler; Daniela Taverna; Gaia Zuccolotto; Isabella Monia Montagner; Antonio Rosato; Federica Tonon; Cristina Zennaro; Chiara Agostinis; Roberta Bulla; Miguel Mano; Giannino Del Sal; Licio Collavin
Journal:  Cell Death Differ       Date:  2018-03-22       Impact factor: 15.828

6.  Innate immunity, inflammation and tumour progression: double-edged swords.

Authors:  A Mantovani; A Ponzetta; A Inforzato; S Jaillon
Journal:  J Intern Med       Date:  2019-03-14       Impact factor: 8.989

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Authors:  Felicitas Rataj; Séverine Planel; Josiane Denis; Caroline Roelants; Odile Filhol; Laurent Guyon; Jean-Jacques Feige; Nadia Cherradi
Journal:  Oncogene       Date:  2019-03-26       Impact factor: 9.867

8.  Small cell lung cancer: Recruitment of macrophages by circulating tumor cells.

Authors:  Gerhard Hamilton; Barbara Rath; Lukas Klameth; Maximilan J Hochmair
Journal:  Oncoimmunology       Date:  2015-10-29       Impact factor: 8.110

9.  PTX3, a Humoral Pattern Recognition Molecule, in Innate Immunity, Tissue Repair, and Cancer.

Authors:  Cecilia Garlanda; Barbara Bottazzi; Elena Magrini; Antonio Inforzato; Alberto Mantovani
Journal:  Physiol Rev       Date:  2018-04-01       Impact factor: 37.312

10.  Mir-21-Sox2 Axis Delineates Glioblastoma Subtypes with Prognostic Impact.

Authors:  Pratheesh Sathyan; Pascal O Zinn; Anantha L Marisetty; Bin Liu; Mohamed Mostafa Kamal; Sanjay K Singh; Pierre Bady; Li Lu; Khalida M Wani; Bethany L Veo; Joy Gumin; Dina Hamada Kassem; Frederick Robinson; Connie Weng; Veerabhadran Baladandayuthapani; Dima Suki; Howard Colman; Krishna P Bhat; Erik P Sulman; Ken Aldape; Rivka R Colen; Roel G W Verhaak; Zhimin Lu; Gregory N Fuller; Suyun Huang; Frederick F Lang; Raymond Sawaya; Monika Hegi; Sadhan Majumder
Journal:  J Neurosci       Date:  2015-11-11       Impact factor: 6.167
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