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Literature DB >> 23664612

The cell-autonomous role of excitatory synaptic transmission in the regulation of neuronal structure and function.

Wei Lu¹, Eric A Bushong, Tiffany P Shih, Mark H Ellisman, Roger A Nicoll.

Abstract

The cell-autonomous role of synaptic transmission in the regulation of neuronal structural and electrical properties is unclear. We have now employed a genetic approach to eliminate glutamatergic synaptic transmission onto individual CA1 pyramidal neurons in a mosaic fashion in vivo. Surprisingly, while electrical properties are profoundly affected in these neurons, as well as inhibitory synaptic transmission, we found little perturbation of neuronal morphology, demonstrating a functional segregation of excitatory synaptic transmission from neuronal morphological development.

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Year: 2013 PMID： 23664612 PMCID： PMC3666354 DOI： 10.1016/j.neuron.2013.02.030

Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173

78 in total

1. Distinct roles for ionotropic and metabotropic glutamate receptors in the maturation of excitatory synapses.

Authors: S N Gomperts; R Carroll; R C Malenka; R A Nicoll
Journal: J Neurosci Date: 2000-03-15 Impact factor: 6.167

2. Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity.

Authors: M Maletic-Savatic; R Malinow; K Svoboda
Journal: Science Date: 1999-03-19 Impact factor: 47.728

3. Dendritic spine dynamics are regulated by monocular deprivation and extracellular matrix degradation.

Authors: Serkan Oray; Ania Majewska; Mriganka Sur
Journal: Neuron Date: 2004-12-16 Impact factor: 17.173

4. Synapse composition and organization following chronic activity blockade in cultured hippocampal neurons.

Authors: Kimberly J Harms; Ann Marie Craig
Journal: J Comp Neurol Date: 2005-09-12 Impact factor: 3.215

5. Activity-dependent regulation of inhibitory synaptic transmission in hippocampal neurons.

Authors: Kenichi N Hartman; Sumon K Pal; Juan Burrone; Venkatesh N Murthy
Journal: Nat Neurosci Date: 2006-04-02 Impact factor: 24.884

6. Environmental enrichment: effects on stereotyped behavior and dendritic morphology.

Authors: Cortney A Turner; Mark H Lewis; Michael A King
Journal: Dev Psychobiol Date: 2003-07 Impact factor: 3.038

7. Long-term sensory deprivation prevents dendritic spine loss in primary somatosensory cortex.

Authors: Yi Zuo; Guang Yang; Elaine Kwon; Wen-Biao Gan
Journal: Nature Date: 2005-07-14 Impact factor: 49.962

8. Spatial training in a complex environment and isolation alter the spine distribution differently in rat CA1 pyramidal cells.

Authors: M B Moser; M Trommald; T Egeland; P Andersen
Journal: J Comp Neurol Date: 1997-04-14 Impact factor: 3.215

9. Excitatory GABA responses in embryonic and neonatal cortical slices demonstrated by gramicidin perforated-patch recordings and calcium imaging.

Authors: D F Owens; L H Boyce; M B Davis; A R Kriegstein
Journal: J Neurosci Date: 1996-10-15 Impact factor: 6.167

10. Stably maintained dendritic spines are associated with lifelong memories.

Authors: Guang Yang; Feng Pan; Wen-Biao Gan
Journal: Nature Date: 2009-11-29 Impact factor: 49.962

46 in total

1. Prelimbic cortex and ventral tegmental area modulate synaptic plasticity differentially in nucleus accumbens during cocaine-reinstated drug seeking.

Authors: Hao-wei Shen; Cassandra D Gipson; Martijn Huits; Peter W Kalivas
Journal: Neuropsychopharmacology Date: 2013-11-15 Impact factor: 7.853

10. A Stem Cell Model of the Motor Circuit Uncouples Motor Neuron Death from Hyperexcitability Induced by SMN Deficiency.

Authors: Christian M Simon; Anna M Janas; Francesco Lotti; Juan Carlos Tapia; Livio Pellizzoni; George Z Mentis
Journal: Cell Rep Date: 2016-07-21 Impact factor: 9.423

The cell-autonomous role of excitatory synaptic transmission in the regulation of neuronal structure and function.

1. Distinct roles for ionotropic and metabotropic glutamate receptors in the maturation of excitatory synapses.

2. Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity.

3. Dendritic spine dynamics are regulated by monocular deprivation and extracellular matrix degradation.

4. Synapse composition and organization following chronic activity blockade in cultured hippocampal neurons.

5. Activity-dependent regulation of inhibitory synaptic transmission in hippocampal neurons.

6. Environmental enrichment: effects on stereotyped behavior and dendritic morphology.

7. Long-term sensory deprivation prevents dendritic spine loss in primary somatosensory cortex.

8. Spatial training in a complex environment and isolation alter the spine distribution differently in rat CA1 pyramidal cells.

9. Excitatory GABA responses in embryonic and neonatal cortical slices demonstrated by gramicidin perforated-patch recordings and calcium imaging.

10. Stably maintained dendritic spines are associated with lifelong memories.

1. Prelimbic cortex and ventral tegmental area modulate synaptic plasticity differentially in nucleus accumbens during cocaine-reinstated drug seeking.

2. Laminar and columnar development of barrel cortex relies on thalamocortical neurotransmission.

Review 3. AMPA-silent synapses in brain development and pathology.

Review 4. Developmental interactions between thalamus and cortex: a true love reciprocal story.

Review 5. Structural Components of Synaptic Plasticity and Memory Consolidation.

6. Excitatory neurons sculpt GABAergic neuronal connectivity in the C. elegans motor circuit.

7. Preferential Targeting of Lateral Entorhinal Inputs onto Newly Integrated Granule Cells.

8. Assembly of Excitatory Synapses in the Absence of Glutamatergic Neurotransmission.

Review 9. Regulation of GABAergic synapse development by postsynaptic membrane proteins.

10. A Stem Cell Model of the Motor Circuit Uncouples Motor Neuron Death from Hyperexcitability Induced by SMN Deficiency.