BACKGROUND: Burkholderia cepacia complex (BCC) has been described as a cause of nosocomial outbreaks. We describe an outbreak of and identify risk factors for nosocomial BCC infections associated with intrinsically contaminated mannitol 3% solution. METHODS: Urinary and bloodstream infection caused by BCC were identified in hospitalized patients who underwent urologic surgery and received intraoperative irrigation of 3% mannitol solution in February 2009. The investigation included retrospective chart review, case control study, procedural review, and culture of mannitol solution. RESULTS: Seven BCC infections were identified. BCC isolates were recovered from blood and/or urine from patients and lots of mannitol in use during the outbreak period. Mannitol solution was produced by a compounding pharmacy. Receipt of larger volumes of contaminated solution was identified as a significant risk factor for infection (odds ratio, 1.5; P value < .05). BCC was also cultured in lots of mannitol in use in other hospitals. CONCLUSION: Manipulated mannitol solution is a potential source of infection. Contamination with paraben-degrading organisms can occur at the time of manufacture. Our findings suggest that contamination of mannitol at a compounding pharmacy occurred. Prompt communication to other hospitals and implementation of infection control measures were effective in avoiding further cases of infection.
BACKGROUND: Burkholderia cepacia complex (BCC) has been described as a cause of nosocomial outbreaks. We describe an outbreak of and identify risk factors for nosocomial BCC infections associated with intrinsically contaminated mannitol 3% solution. METHODS: Urinary and bloodstream infection caused by BCC were identified in hospitalized patients who underwent urologic surgery and received intraoperative irrigation of 3% mannitol solution in February 2009. The investigation included retrospective chart review, case control study, procedural review, and culture of mannitol solution. RESULTS: Seven BCC infections were identified. BCC isolates were recovered from blood and/or urine from patients and lots of mannitol in use during the outbreak period. Mannitol solution was produced by a compounding pharmacy. Receipt of larger volumes of contaminated solution was identified as a significant risk factor for infection (odds ratio, 1.5; P value < .05). BCC was also cultured in lots of mannitol in use in other hospitals. CONCLUSION: Manipulated mannitol solution is a potential source of infection. Contamination with paraben-degrading organisms can occur at the time of manufacture. Our findings suggest that contamination of mannitol at a compounding pharmacy occurred. Prompt communication to other hospitals and implementation of infection control measures were effective in avoiding further cases of infection.
Authors: Rami Sommerstein; Urs Führer; Elia Lo Priore; Carlo Casanova; Dominik M Meinel; Helena Mb Seth-Smith; Andreas Kronenberg; Daniel Koch; Laurence Senn; Andreas F Widmer; Adrian Egli; Jonas Marschall Journal: Euro Surveill Date: 2017-12
Authors: Sören L Becker; Fabian K Berger; Susanne K Feldner; Irem Karliova; Manfred Haber; Alexander Mellmann; Hans-Joachim Schäfers; Barbara Gärtner Journal: Euro Surveill Date: 2018-10
Authors: Matthew M Schaefers; Benjamin X Wang; Nicole M Boisvert; Sarah J Martini; Sarah L Bonney; Christopher W Marshall; Michael T Laub; Vaughn S Cooper; Gregory P Priebe Journal: mBio Date: 2021-08-10 Impact factor: 7.867