Literature DB >> 23663732

miR-34a and the cardiomyopathy of senescence: SALT PNUTS, SALT PNUTS!

Gerald W Dorn1.   

Abstract

The search for eternal youth is age old. In a recent Nature paper, Boon et al. (2013) describe DNA damage mechanisms and cardiac senescence provoked by miR-34a and its target, PNUTS. Interrupting this pathway may prevent age- and stress-induced cardiac degeneration.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Year:  2013        PMID： 23663732      PMCID： PMC3676894          DOI： 10.1016/j.cmet.2013.04.004

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  10 in total

Review 1.  Cellular senescence in cancer and aging.

Authors:  Manuel Collado; Maria A Blasco; Manuel Serrano
Journal:  Cell       Date:  2007-07-27       Impact factor: 41.582

2.  The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response.

Authors:  Helga B Landsverk; Felipe Mora-Bermúdez; Ole J B Landsverk; Grete Hasvold; Soheil Naderi; Oddmund Bakke; Jan Ellenberg; Philippe Collas; Randi G Syljuåsen; Thomas Küntziger
Journal:  EMBO Rep       Date:  2010-10-01       Impact factor: 8.807

3.  MicroRNA-34a regulation of endothelial senescence.

Authors:  Takashi Ito; Shusuke Yagi; Munekazu Yamakuchi
Journal:  Biochem Biophys Res Commun       Date:  2010-07-11       Impact factor: 3.575

4.  Epitranscriptional orchestration of genetic reprogramming is an emergent property of stress-regulated cardiac microRNAs.

Authors:  Yuanxin Hu; Scot J Matkovich; Peter A Hecker; Yan Zhang; John R Edwards; Gerald W Dorn
Journal:  Proc Natl Acad Sci U S A       Date:  2012-11-12       Impact factor: 11.205

5.  Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.

Authors:  S J Lin; P A Defossez; L Guarente
Journal:  Science       Date:  2000-09-22       Impact factor: 47.728

6.  MicroRNA-34a regulates cardiac ageing and function.

Authors:  Reinier A Boon; Kazuma Iekushi; Stefanie Lechner; Timon Seeger; Ariane Fischer; Susanne Heydt; David Kaluza; Karine Tréguer; Guillaume Carmona; Angelika Bonauer; Anton J G Horrevoets; Nathalie Didier; Zenawit Girmatsion; Peter Biliczki; Joachim R Ehrlich; Hugo A Katus; Oliver J Müller; Michael Potente; Andreas M Zeiher; Heiko Hermeking; Stefanie Dimmeler
Journal:  Nature       Date:  2013-02-20       Impact factor: 49.962

7.  TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs.

Authors:  Hyeung Kim; Ok-Hee Lee; Huawei Xin; Liuh-Yow Chen; Jun Qin; Heekyung Kate Chae; Shiaw-Yih Lin; Amin Safari; Dan Liu; Zhou Songyang
Journal:  Nat Struct Mol Biol       Date:  2009-03-15       Impact factor: 15.369

8.  Reduced expression of PNUTS leads to activation of Rb-phosphatase and caspase-mediated apoptosis.

Authors:  Gabriel De Leon; Tara C Sherry; Nancy A Krucher
Journal:  Cancer Biol Ther       Date:  2008-03-05       Impact factor: 4.742

9.  PNUTS functions as a proto-oncogene by sequestering PTEN.

Authors:  Sridhar Kavela; Swapnil R Shinde; Raman Ratheesh; Kotapalli Viswakalyan; Murali D Bashyam; Swarnalata Gowrishankar; Mohana Vamsy; Sujit Pattnaik; Subramanyeshwar Rao; Regulagadda A Sastry; Mukta Srinivasulu; Junjie Chen; Subbareddy Maddika
Journal:  Cancer Res       Date:  2012-11-01       Impact factor: 12.701

10.  Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis.

Authors:  Tsung-Cheng Chang; Erik A Wentzel; Oliver A Kent; Kalyani Ramachandran; Michael Mullendore; Kwang Hyuck Lee; Georg Feldmann; Munekazu Yamakuchi; Marcella Ferlito; Charles J Lowenstein; Dan E Arking; Michael A Beer; Anirban Maitra; Joshua T Mendell
Journal:  Mol Cell       Date:  2007-05-31       Impact factor: 17.970
  10 in total
  5 in total

1.  Biophysical Analysis of the N-Terminal Domain from the Human Protein Phosphatase 1 Nuclear Targeting Subunit PNUTS Suggests an Extended Transcription Factor TFIIS-Like Fold.

Authors:  Thomas Zacharchenko; Igor Barsukov; Daniel J Rigden; Daimark Bennett; Olga Mayans
Journal:  Protein J       Date:  2016-10       Impact factor: 2.371

2.  MiR-34a inhibits migration and invasion by regulating the SIRT1/p53 pathway in human SW480 cells.

Authors:  Mingguang Lai; Gang Du; Ruiyue Shi; Jun Yao; Genhua Yang; Yue Wei; Dingguo Zhang; Zhenglei Xu; Ru Zhang; Yingxue Li; Zicheng Li; Lisheng Wang
Journal:  Mol Med Rep       Date:  2015-01-12       Impact factor: 2.952

Review 3.  Targeting the microRNA-34a as a Novel Therapeutic Strategy for Cardiovascular Diseases.

Authors:  Cun-Cun Hua; Xin-Ming Liu; Li-Rong Liang; Le-Feng Wang; Jiu-Chang Zhong
Journal:  Front Cardiovasc Med       Date:  2022-01-27

4.  PD-1 inhibitor inducing exosomal miR-34a-5p expression mediates the cross talk between cardiomyocyte and macrophage in immune checkpoint inhibitor-related cardiac dysfunction.

Authors:  Wenzheng Xia; Hanbin Chen; Didi Chen; Congying Xie; Meng Hou; Yijia Ye
Journal:  J Immunother Cancer       Date:  2020-10       Impact factor: 13.751

5.  A nanomicelle with miR-34a and doxorubicin reverses the drug resistance of cisplatin in esophageal carcinoma cells by inhibiting SIRT1 signal pathway.

Authors:  Jun Fang; Yuezhen Wang; Zhun Wang; Tieming Xie; Fengqin Yan; Lei Wang; Jianfeng Hua; Fangzheng Wang; Zhenfu Fu; Zhimin Ye
Journal:  Transl Cancer Res       Date:  2020-07       Impact factor: 1.241
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.