PURPOSE: To investigate the frequency of Alzheimer-related dementia in patients with pseudoexfoliation syndrome (PEX). METHODS: Sixty-seven patients with PEX and 67 age-, gender-, and educational-background-matched control subjects were compared for the presence of Alzheimer-related dementia according to DSM- IV-TR. The effects of cataract, glaucoma, additional ocular and systemic disease on the dementia incidence were also evaluated in patients with PEX and the control group. RESULTS: The frequency of Alzheimer-related dementia was higher in patients with PEX (p = 0.0001). The frequency of dementia in patients who had cataract was higher than in patients without cataract (p = 0.003). There was also an association between additional ocular disease and dementia (p < 0.05). However, there was no association between systemic disease and dementia (p > 0.05). Furthermore, there was no difference for the frequency of dementia between patients who had glaucoma or not among patients with PEX (p = 0.953). CONCLUSION: The increased frequency of Alzheimer-related dementia in patients with PEX is important and a possible association between PEX and Alzheimer's disease could be present.
PURPOSE: To investigate the frequency of Alzheimer-related dementia in patients with pseudoexfoliation syndrome (PEX). METHODS: Sixty-seven patients with PEX and 67 age-, gender-, and educational-background-matched control subjects were compared for the presence of Alzheimer-related dementia according to DSM- IV-TR. The effects of cataract, glaucoma, additional ocular and systemic disease on the dementia incidence were also evaluated in patients with PEX and the control group. RESULTS: The frequency of Alzheimer-related dementia was higher in patients with PEX (p = 0.0001). The frequency of dementia in patients who had cataract was higher than in patients without cataract (p = 0.003). There was also an association between additional ocular disease and dementia (p < 0.05). However, there was no association between systemic disease and dementia (p > 0.05). Furthermore, there was no difference for the frequency of dementia between patients who had glaucoma or not among patients with PEX (p = 0.953). CONCLUSION: The increased frequency of Alzheimer-related dementia in patients with PEX is important and a possible association between PEX and Alzheimer's disease could be present.
Authors: Ahmad M Mansour; Anastasios G P Konstas; Hana A Mansour; Abdul R Charbaji; Khalil M El Jawhari Journal: Middle East Afr J Ophthalmol Date: 2021-04-30
Authors: Vasiliki Katsi; Antonios N Pavlidis; Manolis S Kallistratos; Athanasios Fitsios; Athanasios Bratsas; Dimitris Tousoulis; Christodoulos Stefanadis; Athanasios J Manolis; Ioannis Kallikazaros Journal: N Am J Med Sci Date: 2013-08