Literature DB >> 23661161

Structure of the UreD-UreF-UreG-UreE complex in Helicobacter pylori: a model study.

Francesco Biagi1, Francesco Musiani, Stefano Ciurli.   

Abstract

The molecular details of the protein complex formed by UreD, UreF, UreG, and UreE, accessory proteins for urease activation in the carcinogenic bacterium Helicobacter pylori, have been elucidated using computational modeling. The calculated structure of the complex supports the hypothesis of UreF acting as a GTPase activation protein that facilitates GTP hydrolysis by UreG during urease maturation, and provides a rationale for the design of new drugs against infections by ureolytic bacterial pathogens.

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Year:  2013        PMID： 23661161     DOI： 10.1007/s00775-013-1002-8

Source DB:  PubMed          Journal:  J Biol Inorg Chem        ISSN： 0949-8257            Impact factor:   3.358


  54 in total

1.  Protein-protein docking with simultaneous optimization of rigid-body displacement and side-chain conformations.

Authors:  Jeffrey J Gray; Stewart Moughon; Chu Wang; Ora Schueler-Furman; Brian Kuhlman; Carol A Rohl; David Baker
Journal:  J Mol Biol       Date:  2003-08-01       Impact factor: 5.469

2.  A bifunctional urease enhances survival of pathogenic Yersinia enterocolitica and Morganella morganii at low pH.

Authors:  G M Young; D Amid; V L Miller
Journal:  J Bacteriol       Date:  1996-11       Impact factor: 3.490

Review 3.  Structural disorder throws new light on moonlighting.

Authors:  Peter Tompa; Csilla Szász; László Buday
Journal:  Trends Biochem Sci       Date:  2005-09       Impact factor: 13.807

4.  Structural insights into HypB, a GTP-binding protein that regulates metal binding.

Authors:  Raphael Gasper; Andrea Scrima; Alfred Wittinghofer
Journal:  J Biol Chem       Date:  2006-06-28       Impact factor: 5.157

5.  A model-based proposal for the role of UreF as a GTPase-activating protein in the urease active site biosynthesis.

Authors:  Marco Salomone-Stagni; Barbara Zambelli; Francesco Musiani; Stefano Ciurli
Journal:  Proteins       Date:  2007-08-15

6.  Surface, subunit interfaces and interior of oligomeric proteins.

Authors:  J Janin; S Miller; C Chothia
Journal:  J Mol Biol       Date:  1988-11-05       Impact factor: 5.469

7.  Interactions among the seven Helicobacter pylori proteins encoded by the urease gene cluster.

Authors:  Petra Voland; David L Weeks; Elizabeth A Marcus; Christian Prinz; George Sachs; David Scott
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2002-09-04       Impact factor: 4.052

Review 8.  Interplay of metal ions and urease.

Authors:  Eric L Carter; Nicholas Flugga; Jodi L Boer; Scott B Mulrooney; Robert P Hausinger
Journal:  Metallomics       Date:  2009       Impact factor: 4.526

9.  UreG, a chaperone in the urease assembly process, is an intrinsically unstructured GTPase that specifically binds Zn2+.

Authors:  Barbara Zambelli; Massimiliano Stola; Francesco Musiani; Kris De Vriendt; Bart Samyn; Bart Devreese; Jozef Van Beeumen; Paola Turano; Alexander Dikiy; Donald A Bryant; Stefano Ciurli
Journal:  J Biol Chem       Date:  2004-11-12       Impact factor: 5.157

10.  ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures.

Authors:  Meytal Landau; Itay Mayrose; Yossi Rosenberg; Fabian Glaser; Eric Martz; Tal Pupko; Nir Ben-Tal
Journal:  Nucleic Acids Res       Date:  2005-07-01       Impact factor: 16.971
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  9 in total

1.  The Helicobacter pylori HypA·UreE2 Complex Contains a Novel High-Affinity Ni(II)-Binding Site.

Authors:  Heidi Q Hu; Hsin-Ting Huang; Michael J Maroney
Journal:  Biochemistry       Date:  2018-05-10       Impact factor: 3.162

2.  Selectivity of Ni(II) and Zn(II) binding to Sporosarcina pasteurii UreE, a metallochaperone in the urease assembly: a calorimetric and crystallographic study.

Authors:  Barbara Zambelli; Katarzyna Banaszak; Anna Merloni; Agnieszka Kiliszek; Wojciech Rypniewski; Stefano Ciurli
Journal:  J Biol Inorg Chem       Date:  2013-10-15       Impact factor: 3.358

3.  Intrinsic disorder and metal binding in UreG proteins from Archae hyperthermophiles: GTPase enzymes involved in the activation of Ni(II) dependent urease.

Authors:  Manfredi Miraula; Stefano Ciurli; Barbara Zambelli
Journal:  J Biol Inorg Chem       Date:  2015-04-07       Impact factor: 3.358

Review 4.  Metallochaperones and metalloregulation in bacteria.

Authors:  Daiana A Capdevila; Katherine A Edmonds; David P Giedroc
Journal:  Essays Biochem       Date:  2017-05-09       Impact factor: 8.000

5.  Nickel binding properties of Helicobacter pylori UreF, an accessory protein in the nickel-based activation of urease.

Authors:  Barbara Zambelli; Andrea Berardi; Vlad Martin-Diaconescu; Luca Mazzei; Francesco Musiani; Michael J Maroney; Stefano Ciurli
Journal:  J Biol Inorg Chem       Date:  2013-11-30       Impact factor: 3.358

Review 6.  Nickel trafficking system responsible for urease maturation in Helicobacter pylori.

Authors:  Rui-Guang Ge; Dong-Xian Wang; Ming-Cong Hao; Xue-Song Sun
Journal:  World J Gastroenterol       Date:  2013-12-07       Impact factor: 5.742

7.  The conformational response to Zn(II) and Ni(II) binding of Sporosarcina pasteurii UreG, an intrinsically disordered GTPase.

Authors:  Annalisa D'Urzo; Carlo Santambrogio; Rita Grandori; Stefano Ciurli; Barbara Zambelli
Journal:  J Biol Inorg Chem       Date:  2014-09-09       Impact factor: 3.358

8.  Structure of UreG/UreF/UreH complex reveals how urease accessory proteins facilitate maturation of Helicobacter pylori urease.

Authors:  Yu Hang Fong; Ho Chun Wong; Man Hon Yuen; Pak Ho Lau; Yu Wai Chen; Kam-Bo Wong
Journal:  PLoS Biol       Date:  2013-10-08       Impact factor: 8.029

Review 9.  Common themes and unique proteins for the uptake and trafficking of nickel, a metal essential for the virulence of Helicobacter pylori.

Authors:  Hilde de Reuse; Daniel Vinella; Christine Cavazza
Journal:  Front Cell Infect Microbiol       Date:  2013-12-09       Impact factor: 5.293
  9 in total

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