PURPOSE: Oxidative stress has been found to play a key role in several diseases, that range from cancer to neurodegenerative disorders. Besides traditional anti-oxidant agents, in recent years much attention has been focused on nanotechnological solutions, including cerium oxide nanoparticles (nanoceria). METHODS: Thanks to its extraordinary catalytic properties, nanoceria mimics the activity of superoxide dismutase and of catalase, therefore acting as a reactive oxygen species (ROS) scavenger in many biological contexts. In this paper, we report on nanoceria interactions with PC12 cell line, that represents a valuable model for many features of central dopaminergic neurons. RESULTS: Nanoceria confirmed a strong anti-ROS action but, most interestingly, also showed beneficial effects on both cell differentiation and dopamine production. CONCLUSIONS: Even if deeper examinations will be necessary in order to better clarify the mechanisms at the base of the documented effects, nanoceria demonstrated a significant potential as pharmacological agent in the treatment of neurological disorders.
PURPOSE: Oxidative stress has been found to play a key role in several diseases, that range from cancer to neurodegenerative disorders. Besides traditional anti-oxidant agents, in recent years much attention has been focused on nanotechnological solutions, including cerium oxide nanoparticles (nanoceria). METHODS: Thanks to its extraordinary catalytic properties, nanoceria mimics the activity of superoxide dismutase and of catalase, therefore acting as a reactive oxygen species (ROS) scavenger in many biological contexts. In this paper, we report on nanoceria interactions with PC12 cell line, that represents a valuable model for many features of central dopaminergic neurons. RESULTS: Nanoceria confirmed a strong anti-ROS action but, most interestingly, also showed beneficial effects on both cell differentiation and dopamine production. CONCLUSIONS: Even if deeper examinations will be necessary in order to better clarify the mechanisms at the base of the documented effects, nanoceria demonstrated a significant potential as pharmacological agent in the treatment of neurological disorders.
Authors: Michael T Tseng; Xiaoqin Lu; Xiaoxian Duan; Sarita S Hardas; Rukhsana Sultana; Peng Wu; Jason M Unrine; Uschi Graham; D Allan Butterfield; Eric A Grulke; Robert A Yokel Journal: Toxicol Appl Pharmacol Date: 2012-02-20 Impact factor: 4.219
Authors: Soumen Das; Sanjay Singh; Janet M Dowding; Saji Oommen; Amit Kumar; Thi X T Sayle; Shashank Saraf; Chitta R Patra; Nicholas E Vlahakis; Dean C Sayle; William T Self; Sudipta Seal Journal: Biomaterials Date: 2012-08-01 Impact factor: 12.479
Authors: Magdalena Gąssowska; Grzegorz A Czapski; Beata Pająk; Magdalena Cieślik; Anna M Lenkiewicz; Agata Adamczyk Journal: PLoS One Date: 2014-04-10 Impact factor: 3.240