| Literature DB >> 23659457 |
Kavita Sharma1, Aishwarya Iyer, Kundan Sengupta, Harinath Chakrapani.
Abstract
The design, synthesis, and development of INDQ/NO, a novel nitric oxide (NO) prodrug targeted by a bioreductive trigger, are described. INDQ/NO, an indolequinone-diazeniumdiolate is found to be metabolized to produce NO by DT-diaphorase, a bioreductive enzyme that is overexpressed in certain cancers and hypoxic tumors. Cell-based assays revealed that INDQ/NO induces DNA damage and is a potent inhibitor of cancer cell proliferation.Entities:
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Year: 2013 PMID： 23659457 DOI： 10.1021/ol400884v
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005