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Literature DB >> 23659434

Cytotoxic constituents from Psoralea corylifolia.

Ping Song¹, Xin-Zhou Yang, Jing-Quan Yuan.

Abstract

Bioassay directed isolation of the EtOAc extract from a traditional Chinese medicine Psoralea corylifolia resulted in the purification of two isoflavonoids, corylifols D (1) and E (2), along with four known ones. The structures of 1 and 2 were determined by extensive 1D and 2D NMR and MS data analyses. When tested against HepG2 and Hep3B hepatocellular carcinoma cell lines, corylifol A (4) displayed IC50 values of 4.6 and 13.5 μg/ml, respectively.

Entities: Chemical Disease Species

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Year: 2013 PMID： 23659434 DOI： 10.1080/10286020.2013.793181

Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.569

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Cited

6 in total

1. HPLC-based activity profiling of anti-hepatocellular carcinoma constituents from the Tibetan medicine, Caragana tibetica.

Authors: Ping Song; Qiang Wang; Jing-Nan Lv; Chan Xu; Qin-Xiong Lin; Xin-Hua Ma; Mi Huang; Xin-Zhou Yang
Journal: J Huazhong Univ Sci Technolog Med Sci Date: 2015-06-14

2. Metabolism and disposition of corylifol A from Psoralea corylifolia: metabolite mapping, isozyme contribution, species differences and identification of efflux transporters for corylifol A-O-glucuronide in HeLa1A1 cells.

Authors: Yang Li; Jinjin Xu; Chunxia Xu; Zifei Qin; Shishi Li; Liufang Hu; Zhihong Yao; Frank J Gonzalez; Xinsheng Yao
Journal: Xenobiotica Date: 2020-04-01 Impact factor: 1.908

Cytotoxic constituents from Psoralea corylifolia.

1. HPLC-based activity profiling of anti-hepatocellular carcinoma constituents from the Tibetan medicine, Caragana tibetica.

2. Metabolism and disposition of corylifol A from Psoralea corylifolia: metabolite mapping, isozyme contribution, species differences and identification of efflux transporters for corylifol A-O-glucuronide in HeLa1A1 cells.

3. Psoralidin induces autophagy through ROS generation which inhibits the proliferation of human lung cancer A549 cells.

4. Study on the 2-Phenylchroman-4-One Derivatives and their anti-MERS-CoV Activities.

Review 5. Genus Psoralea: A review of the traditional and modern uses, phytochemistry and pharmacology.

6. Bavachinin Induces Oxidative Damage in HepaRG Cells through p38/JNK MAPK Pathways.