I A Ebule1, A N Longdoh, I L Paloheimo. 1. Faculty of Medicine and Biomedical Sciences, University of Yaounde 1/The Yaounde Initiative Foundation, Yaounde, Cameroon. alolevo@yahoo.com
Abstract
BACKGROUND: Helicobacter pylori-infection associated gastritis is known to be a significant risk factor of gastric cancer. Serum levels of Gastrin-17 and Pepsinogen1which are respectively biomarkers of gastric antral and corpus mucosal activity are well known parameters of atrophic gastritis. OBJECTIVES: To determine the prevalence of Helicobacter pylori and atrophic gastritis amongst dyspeptic patients and to compare the production of PGI and G-17 in the various atrophic stages. METHODS: A total of 139 dyspeptic patients aged 46.68±15.50 years [females 106 aged47.23±15.51years, males 33 aged 44.48±14.62] were included during the one year period, March 2008-april 2009 at the district hospital Tombel. The degree of atrophy was determined by the levels of serum pepsinogen1, and gastrin-17 and the presence of Helicobacter pylori antibodies detected by an enzyme immunoassay. RESULTS: The prevalence of Helicobacter pylori was 79.82% and that for atrophic gastritis was 6.6%. A decrease in mean serum levels of gastin-17 along with increasing antral atrophy was observed; the mean serum levels of pepsinogen1 were reduced during progression of corpus atrophy. CONCLUSION: A weak reverse correlation(r =-0.036) was found between Gastrin-17 and Helicobacter pylori antibodies.
BACKGROUND:Helicobacter pylori-infection associated gastritis is known to be a significant risk factor of gastric cancer. Serum levels of Gastrin-17 and Pepsinogen1which are respectively biomarkers of gastric antral and corpus mucosal activity are well known parameters of atrophic gastritis. OBJECTIVES: To determine the prevalence of Helicobacter pylori and atrophic gastritis amongst dyspeptic patients and to compare the production of PGI and G-17 in the various atrophic stages. METHODS: A total of 139 dyspeptic patients aged 46.68±15.50 years [females 106 aged47.23±15.51years, males 33 aged 44.48±14.62] were included during the one year period, March 2008-april 2009 at the district hospital Tombel. The degree of atrophy was determined by the levels of serum pepsinogen1, and gastrin-17 and the presence of Helicobacter pylori antibodies detected by an enzyme immunoassay. RESULTS: The prevalence of Helicobacter pylori was 79.82% and that for atrophic gastritis was 6.6%. A decrease in mean serum levels of gastin-17 along with increasing antral atrophy was observed; the mean serum levels of pepsinogen1 were reduced during progression of corpus atrophy. CONCLUSION: A weak reverse correlation(r =-0.036) was found between Gastrin-17 and Helicobacter pylori antibodies.
Authors: Victor D Pasechnikov; Sergey Z Chukov; Sergey M Kotelevets; Alexander N Mostovov; Varvara P Mernova; Maria B Polyakova Journal: Scand J Gastroenterol Date: 2005-03 Impact factor: 2.423
Authors: N Sande; M Nikulin; I Nilsson; T Wadström; F Laxén; M Härkönen; O Suovaniemi; P Sipponen Journal: Scand J Gastroenterol Date: 2001-09 Impact factor: 2.423
Authors: H Väänänen; M Vauhkonen; T Helske; I Kääriäinen; M Rasmussen; H Tunturi-Hihnala; J Koskenpato; M Sotka; M Turunen; R Sandström; M Ristikankare; A Jussila; P Sipponen Journal: Eur J Gastroenterol Hepatol Date: 2003-08 Impact factor: 2.566