H Lu1, Y Wang, Y Huang, H Shi, Q Xue, S Yang, S He, H Wang. 1. Department of Cardiothoracic Surgery, Nantong University Cancer Hospital, Nantong University, Nantong, 226001, People's Republic of China.
Abstract
PURPOSE: The c-Myb transcription factor controls differentiation and proliferation in hematopoietic and other cell types, and has latent in regulation during the cell cycle. Recent studies suggested that deregulation of c-Myb expression plays a key role in oncogenesis. To investigate the potential roles of c-Myb in esophageal carcinoma, expression of c-Myb was examined in human esophageal carcinoma samples. METHODS: Immunohistochemistry and Western blot analysis were performed for c-Myb in 87 esophageal carcinoma samples. The data were correlated with clinicopathological features. The univariate and multivariate survival analyses were also performed to determine their prognostic significance. RESULTS: c-Myb was overexpressed in esophageal carcinoma as compared with the adjacent normal tissue. High expression of c-Myb was associated with histological grade and was positively correlated with proliferation marker Ki-67 (P = 0.001). Univariate analysis showed that c-Myb expression was associated with poor prognosis (P < 0.001). Multivariate analysis indicated that c-Myb was an independent prognostic marker for esophageal carcinoma (P < 0.001). While in vitro, following release from serum starvation of TE-1 esophageal carcinoma cell, the expression of c-Myb was upregulated. CONCLUSIONS: Our results suggested that c-Myb overexpression is involved in the pathogenesis of esophageal carcinoma; it may be a favorable independent poor prognostic parameter for esophageal carcinoma.
PURPOSE: The c-Myb transcription factor controls differentiation and proliferation in hematopoietic and other cell types, and has latent in regulation during the cell cycle. Recent studies suggested that deregulation of c-Myb expression plays a key role in oncogenesis. To investigate the potential roles of c-Myb in esophageal carcinoma, expression of c-Myb was examined in humanesophageal carcinoma samples. METHODS: Immunohistochemistry and Western blot analysis were performed for c-Myb in 87 esophageal carcinoma samples. The data were correlated with clinicopathological features. The univariate and multivariate survival analyses were also performed to determine their prognostic significance. RESULTS:c-Myb was overexpressed in esophageal carcinoma as compared with the adjacent normal tissue. High expression of c-Myb was associated with histological grade and was positively correlated with proliferation marker Ki-67 (P = 0.001). Univariate analysis showed that c-Myb expression was associated with poor prognosis (P < 0.001). Multivariate analysis indicated that c-Myb was an independent prognostic marker for esophageal carcinoma (P < 0.001). While in vitro, following release from serum starvation of TE-1 esophageal carcinoma cell, the expression of c-Myb was upregulated. CONCLUSIONS: Our results suggested that c-Myb overexpression is involved in the pathogenesis of esophageal carcinoma; it may be a favorable independent poor prognostic parameter for esophageal carcinoma.
Authors: Honor Hugo; Alina Cures; Nirosha Suraweera; Yvette Drabsch; Damian Purcell; Theo Mantamadiotis; Wayne Phillips; Alex Dobrovic; Gabriella Zupi; Thomas J Gonda; Barry Iacopetta; Robert G Ramsay Journal: Genes Chromosomes Cancer Date: 2006-12 Impact factor: 5.006
Authors: Kylie T Greig; Carolyn A de Graaf; James M Murphy; Marina R Carpinelli; Swee Heng Milon Pang; Jon Frampton; Benjamin T Kile; Douglas J Hilton; Stephen L Nutt Journal: Blood Date: 2010-02-03 Impact factor: 22.113
Authors: Takaomi Okawa; Carmen Z Michaylira; Jiri Kalabis; Douglas B Stairs; Hiroshi Nakagawa; Claudia D Andl; Cameron N Johnstone; Andres J Klein-Szanto; Wafik S El-Deiry; Edna Cukierman; Meenhard Herlyn; Anil K Rustgi Journal: Genes Dev Date: 2007-11-01 Impact factor: 11.361
Authors: C Grabher; E M Payne; A B Johnston; N Bolli; E Lechman; J E Dick; J P Kanki; A T Look Journal: Leukemia Date: 2010-11-16 Impact factor: 11.528