OBJECTIVES: This study aimed to immunohistochemically evaluate staged guided bone regeneration and osseointegration of titanium implants using two bone graft substitutes in combination with a polyethylene glycol (PEG) membrane in a dog model. MATERIALS AND METHODS: Saddle-type alveolar ridge defects were prepared in the lower jaws of 12 foxhounds and randomly filled with a natural bone mineral (NBM) or a biphasic calcium phosphate (SBC) and covered with an in situ gelling PEG membrane. After a healing period of 8 and 12 weeks (six animals each), modSLA titanium implants were inserted to heal in a submerged position. At 8 + 2 and 12 + 2 weeks, respectively, dissected blocks were processed for immunohistochemical analysis [osteocalcin (OC)]. RESULTS: After 8 + 2 weeks, mean OC values (%) tended to be higher in the NBM group (NBM, 32.7 ± 8.9%), but failed to reach statistical significance over the SBC group (SBC, 24.4 ± 6.6%). After 12 + 2 weeks, mean OC values decreased in both groups and was almost identical in both groups (NBM 1.6 ± 1.2%/SBC 2.1 ± 1.4%). CONCLUSION: It was concluded that all augmentation procedures investigated were characterised by a comparable OC activity during the process of bone regeneration and osseointegration of modSLA titanium implants.
OBJECTIVES: This study aimed to immunohistochemically evaluate staged guided bone regeneration and osseointegration of titanium implants using two bone graft substitutes in combination with a polyethylene glycol (PEG) membrane in a dog model. MATERIALS AND METHODS: Saddle-type alveolar ridge defects were prepared in the lower jaws of 12 foxhounds and randomly filled with a natural bone mineral (NBM) or a biphasic calcium phosphate (SBC) and covered with an in situ gelling PEG membrane. After a healing period of 8 and 12 weeks (six animals each), modSLA titanium implants were inserted to heal in a submerged position. At 8 + 2 and 12 + 2 weeks, respectively, dissected blocks were processed for immunohistochemical analysis [osteocalcin (OC)]. RESULTS: After 8 + 2 weeks, mean OC values (%) tended to be higher in the NBM group (NBM, 32.7 ± 8.9%), but failed to reach statistical significance over the SBC group (SBC, 24.4 ± 6.6%). After 12 + 2 weeks, mean OC values decreased in both groups and was almost identical in both groups (NBM 1.6 ± 1.2%/SBC 2.1 ± 1.4%). CONCLUSION: It was concluded that all augmentation procedures investigated were characterised by a comparable OC activity during the process of bone regeneration and osseointegration of modSLA titanium implants.
Authors: T A Owen; M Aronow; V Shalhoub; L M Barone; L Wilming; M S Tassinari; M B Kennedy; S Pockwinse; J B Lian; G S Stein Journal: J Cell Physiol Date: 1990-06 Impact factor: 6.384
Authors: Frank Schwarz; Daniel Ferrari; Martin Sager; Monika Herten; Brigitte Hartig; Jürgen Becker Journal: Clin Oral Implants Res Date: 2009-08-30 Impact factor: 5.977
Authors: Stuart J Froum; Stephen S Wallace; Sang-Choon Cho; Nicolas Elian; Dennis P Tarnow Journal: Int J Periodontics Restorative Dent Date: 2008-06 Impact factor: 1.840