OBJECTIVES: Due to the need for suitable donors for heart transplantation (HTx), older grafts and grafts with prolonged graft ischaemic time (GIT) are accepted. The impact of GIT and donor age on post-transplant cardiac function has not been examined with either newer echocardiographic techniques (tissue Doppler imaging, TDI) or cardiopulmonary exercise testing (CPET). Thus, we studied the influence of GIT and donor age on post-transplant cardiac function and exercise capacity. METHODS: Fifty-two stable recipients underwent echocardiography with colour TDI and CPET at a median of 4 years after HTx. Left ventricular (LV) systolic (s') and early diastolic (e') mitral annular velocities, right ventricular (RV) s', RVe' as well as LV ejection fraction (EF) and VO(2peak) were analysed. RESULTS: HTx recipients with GIT ≥ median value (200 min) had significantly lower septal LVs' (15%, P = 0.005), LVEF (9%, P = 0.015), RVs' (21%, P = 0.007), septal LVe' (22%, P = 0.001) and RVe' velocities (23%, P = 0.011), and slightly lower VO(2peak) (P = 0.098). Recipients with grafts from donor ≥ median age (37 years) had significantly lower LVe' velocities (septal LVe' P = 0.047 and lateral LVe' P = 0.010), but not LV systolic or RV parameters. CONCLUSIONS: Prolonged GIT impairs both systolic and diastolic function at the interventricular septum and RV free wall, while increasing donor age impairs LV diastolic function. The duration of graft ischaemia and donor age should be taken into account when evaluating for cardiac dysfunction in HTx recipients.
OBJECTIVES: Due to the need for suitable donors for heart transplantation (HTx), older grafts and grafts with prolonged graft ischaemic time (GIT) are accepted. The impact of GIT and donor age on post-transplant cardiac function has not been examined with either newer echocardiographic techniques (tissue Doppler imaging, TDI) or cardiopulmonary exercise testing (CPET). Thus, we studied the influence of GIT and donor age on post-transplant cardiac function and exercise capacity. METHODS: Fifty-two stable recipients underwent echocardiography with colour TDI and CPET at a median of 4 years after HTx. Left ventricular (LV) systolic (s') and early diastolic (e') mitral annular velocities, right ventricular (RV) s', RVe' as well as LV ejection fraction (EF) and VO(2peak) were analysed. RESULTS: HTx recipients with GIT ≥ median value (200 min) had significantly lower septal LVs' (15%, P = 0.005), LVEF (9%, P = 0.015), RVs' (21%, P = 0.007), septal LVe' (22%, P = 0.001) and RVe' velocities (23%, P = 0.011), and slightly lower VO(2peak) (P = 0.098). Recipients with grafts from donor ≥ median age (37 years) had significantly lower LVe' velocities (septal LVe' P = 0.047 and lateral LVe' P = 0.010), but not LV systolic or RV parameters. CONCLUSIONS: Prolonged GIT impairs both systolic and diastolic function at the interventricular septum and RV free wall, while increasing donor age impairs LV diastolic function. The duration of graft ischaemia and donor age should be taken into account when evaluating for cardiac dysfunction in HTx recipients.
Authors: Luke W Schroeder; Shahryar M Chowdhury; Ali L Burnette; Minoo N Kavarana; G Hamilton Baker; Andrew J Savage; Andrew M Atz; Ryan J Butts Journal: Pediatr Cardiol Date: 2017-10-31 Impact factor: 1.655
Authors: Sarah L Longnus; Veronika Mathys; Monika Dornbierer; Florian Dick; Thierry P Carrel; Hendrik T Tevaearai Journal: Nat Rev Cardiol Date: 2014-04-15 Impact factor: 32.419
Authors: Shahryar M Chowdhury; Ryan J Butts; Anthony M Hlavacek; Carolyn L Taylor; Karen S Chessa; Varsha M Bandisode; Girish S Shirali; Arni Nutting; G Hamilton Baker Journal: J Am Soc Echocardiogr Date: 2017-12-13 Impact factor: 5.251
Authors: Mayuko Uehara; Zhabiz Solhjou; Naima Banouni; Vivek Kasinath; Ye Xiaqun; Li Dai; Osman Yilmam; Mine Yilmaz; Takaharu Ichimura; Paolo Fiorina; Paulo N Martins; Shunsuke Ohori; Indira Guleria; Omar H Maarouf; Stefan G Tullius; Martina M McGrath; Reza Abdi Journal: Sci Rep Date: 2018-02-06 Impact factor: 4.379