Literature DB >> 23653041

Neuroblastoma: a rare cause of a limping child. How to avoid a delayed diagnosis?

Rishee Parmar1, Farokh Wadia, Rafik Yassa, Michalis Zenios.   

Abstract

UNLABELLED: Neuroblastoma is the most common solid extracranial tumor of childhood. Even though >25% of presentations are orthopaedic in nature, ranging from a limp to lower limb paralysis, neuroblastoma is a rare cause of limping in childhood and can therefore be easily missed by the admitting orthopaedic surgeon. Four cases of metastatic neuroblastoma are reported who all presented with hip pain within the last 3 years at Royal Manchester Children's Hospital. They all posed a diagnostic dilemma and an alternative diagnosis was initially made. A simple screening examination of the abdomen after ultrasonographic hip examination for sepsis would have led to an earlier diagnosis in all 4 cases. We suggest that including the abdomen in children undergoing a hip sonographic examination in those who are slightly atypical in nature or have indications of malignancy may lead to an early diagnosis of this rare cause of hip pain. LEVEL OF EVIDENCE: IV.

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Year:  2013        PMID: 23653041     DOI: 10.1097/BPO.0b013e318279c636

Source DB:  PubMed          Journal:  J Pediatr Orthop        ISSN: 0271-6798            Impact factor:   2.324


  5 in total

1.  Down-Regulation of Phosphoribosyl Pyrophosphate Synthetase 1 Inhibits Neuroblastoma Cell Proliferation.

Authors:  Jifu Li; Junhong Ye; Shunqin Zhu; Hongjuan Cui
Journal:  Cells       Date:  2019-08-22       Impact factor: 6.600

2.  Low DLG2 gene expression, a link between 11q-deleted and MYCN-amplified neuroblastoma, causes forced cell cycle progression, and predicts poor patient survival.

Authors:  Simon Keane; Sophie Améen; Angelica Lindlöf; Katarina Ejeskär
Journal:  Cell Commun Signal       Date:  2020-04-20       Impact factor: 5.712

3.  Metastatic neuroblastoma presenting without a primary tumor: A case report.

Authors:  Ahmed Hafez Mousa; Abdullah Baothman; Abdelrahman Waleed Alsayed; Mohammed Aahid Rozan; Yousef Jehad Ghannam; Abdullatif Ibrahim; Amal Farid Mostafa
Journal:  Radiol Case Rep       Date:  2022-04-13

4.  The Diagnosis of Iliac Bone Destruction in Children: 22 Cases from Two Centres.

Authors:  Xiangshui Sun; Yue Lou; Xiaodong Wang
Journal:  Biomed Res Int       Date:  2016-08-08       Impact factor: 3.411

5.  Irritable Hip as the Inaugural Symptom for Neuroblastoma.

Authors:  Sara Alves da Silva; Jorge Mendes; João Carvalho; Hélder Nogueira; Helena Barroca; Margarida Fernandes; Edite Tomás
Journal:  Case Rep Orthop       Date:  2018-06-28
  5 in total

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