PURPOSE: Although the data are promising from limited studies with technetium-99m ubiquicidin (Tc-UBI) scintigraphy in detection of infection in humans, these studies have had a limited sample size. This study was conducted to provide a systematic review and meta-analysis of the reported diagnostic accuracy of Tc-UBI scintigraphy in detection of an infectious process. MATERIALS AND METHODS: The PubMed/MEDLINE, Web of Science, EMBASE, and Google Scholar literature databases were systematically searched to find the relevant human studies on Tc-UBI scintigraphy. For each eligible study, the true-positive, false-positive, true-negative, and false-negative findings at Tc-UBI scintigraphy were recorded, and the overall statistical parameters were acquired. RESULT: Ten studies carried out from 2004 to 2010 were included in the analysis. The pooled data sensitivity was 94.5 % and with a 95% confidence interval of 91.2%-96.8%. The pooled specificity was still as high as about 92.7%. The range of reported specificity was from 80% to 100%. The overall accuracy was 93.7% (95% CI: 91.2%-95.7%). CONCLUSION: The study demonstrated that Tc-UBI scintigraphy can be used to identify an infectious process with admirable accuracy in early views; however, further investigations are recommended.
PURPOSE: Although the data are promising from limited studies with technetium-99m ubiquicidin (Tc-UBI) scintigraphy in detection of infection in humans, these studies have had a limited sample size. This study was conducted to provide a systematic review and meta-analysis of the reported diagnostic accuracy of Tc-UBI scintigraphy in detection of an infectious process. MATERIALS AND METHODS: The PubMed/MEDLINE, Web of Science, EMBASE, and Google Scholar literature databases were systematically searched to find the relevant human studies on Tc-UBI scintigraphy. For each eligible study, the true-positive, false-positive, true-negative, and false-negative findings at Tc-UBI scintigraphy were recorded, and the overall statistical parameters were acquired. RESULT: Ten studies carried out from 2004 to 2010 were included in the analysis. The pooled data sensitivity was 94.5 % and with a 95% confidence interval of 91.2%-96.8%. The pooled specificity was still as high as about 92.7%. The range of reported specificity was from 80% to 100%. The overall accuracy was 93.7% (95% CI: 91.2%-95.7%). CONCLUSION: The study demonstrated that Tc-UBI scintigraphy can be used to identify an infectious process with admirable accuracy in early views; however, further investigations are recommended.
Authors: Mick M Welling; Clarize M de Korne; Silvia J Spa; Danny M van Willigen; Albertus W Hensbergen; Anton Bunschoten; Nikolas Duszenko; Wiep Klaas Smits; Meta Roestenberg; Fijs W B van Leeuwen Journal: ACS Infect Dis Date: 2019-05-02 Impact factor: 5.084
Authors: Marjolein Heuker; Anna Gomes; Jan Maarten van Dijl; Gooitzen M van Dam; Alexander W Friedrich; Bhanu Sinha; Marleen van Oosten Journal: Clin Transl Imaging Date: 2016-07-16
Authors: Ahsan R Akram; Nicolaos Avlonitis; Annamaria Lilienkampf; Ana M Perez-Lopez; Neil McDonald; Sunay V Chankeshwara; Emma Scholefield; Christopher Haslett; Mark Bradley; Kevin Dhaliwal Journal: Chem Sci Date: 2015-06-29 Impact factor: 9.825