Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Targeting RAF-MEK-ERK kinase-scaffold interactions in cancer.

Literature DB >> 23652103

Targeting RAF-MEK-ERK kinase-scaffold interactions in cancer.

Darrin D Stuart¹, William R Sellers.

Abstract

Entities: Disease Gene

Mesh：

Substances：

Year: 2013 PMID： 23652103 DOI： 10.1038/nm.3195

Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440

× No keyword cloud information.

12 in total

1. Improved survival with MEK inhibition in BRAF-mutated melanoma.

Authors: Keith T Flaherty; Caroline Robert; Peter Hersey; Paul Nathan; Claus Garbe; Mohammed Milhem; Lev V Demidov; Jessica C Hassel; Piotr Rutkowski; Peter Mohr; Reinhard Dummer; Uwe Trefzer; James M G Larkin; Jochen Utikal; Brigitte Dreno; Marta Nyakas; Mark R Middleton; Jürgen C Becker; Michelle Casey; Laurie J Sherman; Frank S Wu; Daniele Ouellet; Anne-Marie Martin; Kiran Patel; Dirk Schadendorf
Journal: N Engl J Med Date: 2012-06-04 Impact factor: 91.245

2. Resistance to BRAF inhibition in melanomas.

Authors: David B Solit; Neal Rosen
Journal: N Engl J Med Date: 2011-02-24 Impact factor: 91.245

3. Inhibition of mutated, activated BRAF in metastatic melanoma.

Authors: Keith T Flaherty; Igor Puzanov; Kevin B Kim; Antoni Ribas; Grant A McArthur; Jeffrey A Sosman; Peter J O'Dwyer; Richard J Lee; Joseph F Grippo; Keith Nolop; Paul B Chapman
Journal: N Engl J Med Date: 2010-08-26 Impact factor: 91.245

4. IQGAP1 is a scaffold for mitogen-activated protein kinase signaling.

Authors: Monideepa Roy; Zhigang Li; David B Sacks
Journal: Mol Cell Biol Date: 2005-09 Impact factor: 4.272

Review 5. IQGAP1 and its binding proteins control diverse biological functions.

Authors: Colin D White; Huseyin H Erdemir; David B Sacks
Journal: Cell Signal Date: 2011-12-11 Impact factor: 4.315

6. MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study.

Authors: Paolo A Ascierto; Dirk Schadendorf; Carola Berking; Sanjiv S Agarwala; Carla Ml van Herpen; Paola Queirolo; Christian U Blank; Axel Hauschild; J Thaddeus Beck; Annie St-Pierre; Faiz Niazi; Simon Wandel; Malte Peters; Angela Zubel; Reinhard Dummer
Journal: Lancet Oncol Date: 2013-02-13 Impact factor: 41.316

7. Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study.

Authors: Pasi A Jänne; Alice T Shaw; José Rodrigues Pereira; Gaëlle Jeannin; Johan Vansteenkiste; Carlos Barrios; Fabio Andre Franke; Lynda Grinsted; Victoria Zazulina; Paul Smith; Ian Smith; Lucio Crinò
Journal: Lancet Oncol Date: 2012-11-28 Impact factor: 41.316

Review 8. Protein scaffolds in MAP kinase signalling.

Authors: Matthew D Brown; David B Sacks
Journal: Cell Signal Date: 2008-12-03 Impact factor: 4.315

9. IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors.

Authors: Katherine L Jameson; Pawel K Mazur; Ashley M Zehnder; Jiajing Zhang; Brian Zarnegar; Julien Sage; Paul A Khavari
Journal: Nat Med Date: 2013-04-21 Impact factor: 53.440

Review 10. IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis.

Authors: Colin D White; Matthew D Brown; David B Sacks
Journal: FEBS Lett Date: 2009-05-09 Impact factor: 4.124

12 in total

1. Patient Mutation Directed shRNA Screen Uncovers Novel Bladder Tumor Growth Suppressors.

Authors: Jonathan Hensel; Jason E Duex; Charles Owens; Garrett M Dancik; Michael G Edwards; Henry F Frierson; Dan Theodorescu
Journal: Mol Cancer Res Date: 2015-06-15 Impact factor: 5.852

2. The WW domain of the scaffolding protein IQGAP1 is neither necessary nor sufficient for binding to the MAPKs ERK1 and ERK2.

Authors: A Jane Bardwell; Leonila Lagunes; Ronak Zebarjedi; Lee Bardwell
Journal: J Biol Chem Date: 2017-04-10 Impact factor: 5.157

3. IQGAP1 promotes CXCR4 chemokine receptor function and trafficking via EEA-1+ endosomes.

Authors: Adebowale O Bamidele; Kimberly N Kremer; Petra Hirsova; Ian C Clift; Gregory J Gores; Daniel D Billadeau; Karen E Hedin
Journal: J Cell Biol Date: 2015-07-20 Impact factor: 10.539

4. Differential transcriptome profile of peripheral white cells to identify biomarkers involved in oxaliplatin induced neuropathy.

Authors: Manuel Morales; Julio Ávila; Rebeca González-Fernández; Laia Boronat; María Luisa Soriano; Pablo Martín-Vasallo
Journal: J Pers Med Date: 2014-06-05

5. Prediction of scaffold proteins based on protein interaction and domain architectures.

Authors: Kimin Oh; Gwan-Su Yi
Journal: BMC Bioinformatics Date: 2016-07-28 Impact factor: 3.169

6. Knockdown of NEAT1 restrained the malignant progression of glioma stem cells by activating microRNA let-7e.

Authors: Wei Gong; Jian Zheng; Xiaobai Liu; Jun Ma; Yunhui Liu; Yixue Xue
Journal: Oncotarget Date: 2016-09-20

7. Extracellular vesicle-mediated phenotype switching in malignant and non-malignant colon cells.

Authors: Hillary E Mulvey; Audrey Chang; Jason Adler; Michael Del Tatto; Kimberly Perez; Peter J Quesenberry; Devasis Chatterjee
Journal: BMC Cancer Date: 2015-08-01 Impact factor: 4.430

8. High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells: interaction with IQ motif-containing factors.

Authors: Tyler J W Robinson; Melody Pai; Jeff C Liu; Frederick Vizeacoumar; Thomas Sun; Sean E Egan; Alessandro Datti; Jing Huang; Eldad Zacksenhaus
Journal: Cell Cycle Date: 2013-08-12 Impact factor: 4.534

9. Stabilization of Sur8 via PKCα/δ degradation promotes transformation and migration of colorectal cancer cells.

Authors: Kug Hwa Lee; Woo-Jeong Jeong; Pu-Hyeon Cha; Sang-Kyu Lee; Do Sik Min; Kang-Yell Choi
Journal: Oncotarget Date: 2017-12-14

Review 10. The p38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells.

Authors: Isabelle Corre; François Paris; Jacques Huot
Journal: Oncotarget Date: 2017-05-29