Literature DB >> 23652093

New findings rejuvenate age-old drug development field.

Cassandra Willyard.   

Abstract

Mesh：

Substances：

Year:  2013        PMID： 23652093     DOI： 10.1038/nm0513-520

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


× No keyword cloud information.
  12 in total

1.  Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.

Authors:  Richard A Miller; David E Harrison; C M Astle; Joseph A Baur; Angela Rodriguez Boyd; Rafael de Cabo; Elizabeth Fernandez; Kevin Flurkey; Martin A Javors; James F Nelson; Carlos J Orihuela; Scott Pletcher; Zelton Dave Sharp; David Sinclair; Joseph W Starnes; J Erby Wilkinson; Nancy L Nadon; Randy Strong
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2010-10-25       Impact factor: 6.053

2.  Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.

Authors:  Kevin J Pearson; Joseph A Baur; Kaitlyn N Lewis; Leonid Peshkin; Nathan L Price; Nazar Labinskyy; William R Swindell; Davida Kamara; Robin K Minor; Evelyn Perez; Hamish A Jamieson; Yongqing Zhang; Stephen R Dunn; Kumar Sharma; Nancy Pleshko; Laura A Woollett; Anna Csiszar; Yuji Ikeno; David Le Couteur; Peter J Elliott; Kevin G Becker; Placido Navas; Donald K Ingram; Norman S Wolf; Zoltan Ungvari; David A Sinclair; Rafael de Cabo
Journal:  Cell Metab       Date:  2008-07-03       Impact factor: 27.287

3.  Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man.

Authors:  Ethan Hoffmann; Jeff Wald; Siva Lavu; John Roberts; Claire Beaumont; Jon Haddad; Peter Elliott; Christoph Westphal; Eric Jacobson
Journal:  Br J Clin Pharmacol       Date:  2013-01       Impact factor: 4.335

4.  Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study.

Authors:  Julie A Mattison; George S Roth; T Mark Beasley; Edward M Tilmont; April M Handy; Richard L Herbert; Dan L Longo; David B Allison; Jennifer E Young; Mark Bryant; Dennis Barnard; Walter F Ward; Wenbo Qi; Donald K Ingram; Rafael de Cabo
Journal:  Nature       Date:  2012-09-13       Impact factor: 49.962

5.  Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice.

Authors:  Randy Strong; Richard A Miller; Clinton M Astle; Joseph A Baur; Rafael de Cabo; Elizabeth Fernandez; Wen Guo; Martin Javors; James L Kirkland; James F Nelson; David A Sinclair; Bruce Teter; David Williams; Nurulain Zaveri; Nancy L Nadon; David E Harrison
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2012-03-26       Impact factor: 6.053

6.  Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.

Authors:  Dudley W Lamming; Lan Ye; Pekka Katajisto; Marcus D Goncalves; Maki Saitoh; Deanna M Stevens; James G Davis; Adam B Salmon; Arlan Richardson; Rexford S Ahima; David A Guertin; David M Sabatini; Joseph A Baur
Journal:  Science       Date:  2012-03-30       Impact factor: 47.728

7.  Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration.

Authors:  Su-Ju Lin; Matt Kaeberlein; Alex A Andalis; Lori A Sturtz; Pierre-Antoine Defossez; Valeria C Culotta; Gerald R Fink; Leonard Guarente
Journal:  Nature       Date:  2002-07-18       Impact factor: 49.962

8.  Evidence for a common mechanism of SIRT1 regulation by allosteric activators.

Authors:  Basil P Hubbard; Ana P Gomes; Han Dai; Jun Li; April W Case; Thomas Considine; Thomas V Riera; Jessica E Lee; Sook Yen E; Dudley W Lamming; Bradley L Pentelute; Eli R Schuman; Linda A Stevens; Alvin J Y Ling; Sean M Armour; Shaday Michan; Huizhen Zhao; Yong Jiang; Sharon M Sweitzer; Charles A Blum; Jeremy S Disch; Pui Yee Ng; Konrad T Howitz; Anabela P Rolo; Yoshitomo Hamuro; Joel Moss; Robert B Perni; James L Ellis; George P Vlasuk; David A Sinclair
Journal:  Science       Date:  2013-03-08       Impact factor: 47.728

9.  Rapamycin slows aging in mice.

Authors:  John E Wilkinson; Lisa Burmeister; Susan V Brooks; Chi-Chao Chan; Sabrina Friedline; David E Harrison; James F Hejtmancik; Nancy Nadon; Randy Strong; Lauren K Wood; Maria A Woodward; Richard A Miller
Journal:  Aging Cell       Date:  2012-06-04       Impact factor: 9.304

10.  Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.

Authors:  David E Harrison; Randy Strong; Zelton Dave Sharp; James F Nelson; Clinton M Astle; Kevin Flurkey; Nancy L Nadon; J Erby Wilkinson; Krystyna Frenkel; Christy S Carter; Marco Pahor; Martin A Javors; Elizabeth Fernandez; Richard A Miller
Journal:  Nature       Date:  2009-07-08       Impact factor: 49.962
View more
  1 in total

1.  Disruption of mammalian target of rapamycin complex 1 in macrophages decreases chemokine gene expression and atherosclerosis.

Authors:  Ding Ai; Hongfeng Jiang; Marit Westerterp; Andrew J Murphy; Mi Wang; Anjali Ganda; Sandra Abramowicz; Carrie Welch; Felicidad Almazan; Yi Zhu; Yury I Miller; Alan R Tall
Journal:  Circ Res       Date:  2014-03-31       Impact factor: 17.367
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.