Literature DB >> 2365068

Interaction of benzoquinones with mitochondria interferes with oxidative phosphorylation characteristics.

D W Makawiti1, V N Konji, J O Olowookere.   

Abstract

Studies with four benzoquinones, viz. juglone, embelin, maesaquinone and maesanin, on rat liver mitochondria oxidative phosphorylation have been carried out. Three of the benzoquinones are uncouplers in the order juglone greater than maesoquinone greater than embelin, while maesanin is an inhibitor of electron transport and oxidative phosphorylation.

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Year:  1990        PMID： 2365068     DOI： 10.1016/0014-5793(90)81497-c

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  5 in total

1.  Activation of endothelial nitric oxide synthase by the pro-apoptotic drug embelin: Striking discrepancy between nitric oxide-mediated cyclic GMP accumulation and L-citrulline formation.

Authors:  Kurt Schmidt; Jens Martens-Lobenhoffer; Andreas Meinitzer; Wolfgang F Graier; Christina M Torres; Richard C Venema; Bernd Mayer
Journal:  Nitric Oxide       Date:  2010-02-06       Impact factor: 4.427

2.  Differential toxicity of juglone (5-hydroxy-1,4-naphthoquinone) and related naphthoquinones to saturniid moths.

Authors:  R L Thiboldeaux; R L Lindroth; J W Tracy
Journal:  J Chem Ecol       Date:  1994-07       Impact factor: 2.626

3.  Targeting Mortalin by Embelin Causes Activation of Tumor Suppressor p53 and Deactivation of Metastatic Signaling in Human Breast Cancer Cells.

Authors:  Nupur Nigam; Abhinav Grover; Sukriti Goyal; Shashank P Katiyar; Priyanshu Bhargava; Pi-Chao Wang; Durai Sundar; Sunil C Kaul; Renu Wadhwa
Journal:  PLoS One       Date:  2015-09-16       Impact factor: 3.240

4.  Activation of p38/JNK pathway is responsible for embelin induced apoptosis in lung cancer cells: transitional role of reactive oxygen species.

Authors:  Deepa R Avisetti; K Suresh Babu; Shasi V Kalivendi
Journal:  PLoS One       Date:  2014-01-22       Impact factor: 3.240

5.  Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing.

Authors:  Oliver Coutelle; Hue-Tran Hornig-Do; Axel Witt; Maria Andree; Lars M Schiffmann; Michael Piekarek; Kerstin Brinkmann; Jens M Seeger; Maxim Liwschitz; Satomi Miwa; Michael Hallek; Martin Krönke; Aleksandra Trifunovic; Sabine A Eming; Rudolf J Wiesner; Ulrich T Hacker; Hamid Kashkar
Journal:  EMBO Mol Med       Date:  2014-05       Impact factor: 12.137
  5 in total

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