Literature DB >> 2365067

Cloning and expression of a cDNA encoding a novel human neurotrophic factor.

Y Kaisho1, K Yoshimura, K Nakahama.   

Abstract

A cDNA encoding a novel human neurotrophic factor (designated nerve growth factor-2; NGF-2) was cloned from a human glioma cDNA library using a synthetic DNA corresponding to human nerve growth factor (NGF). The cloned cDNA encodes a polypeptide composed of 257 amino acid residues including a prepro-sequence of 138 residues and a mature region of 119 residues. The amino acid sequence of human NGF-2 exhibits 58% similarity with that of human NGF. Conditioned medium of COS-7 cells transfected with an expression plasmid for human NGF-2 cDNA supported the survival of sensory neurons isolated from dorsal root ganglia of embryonic chicks. A 1.5 kb of NGF-2 mRNA can be detected from an early development stage in rat brain, by Northern blotting analysis.

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Year:  1990        PMID： 2365067     DOI： 10.1016/0014-5793(90)81536-w

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  23 in total

1.  Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 complement and cooperate with each other sequentially during visceral neuron development.

Authors:  W M ElShamy; P Ernfors
Journal:  J Neurosci       Date:  1997-11-15       Impact factor: 6.167

Review 2.  The response of motoneurons to neurotrophins.

Authors:  M Sendtner; B Holtmann; R A Hughes
Journal:  Neurochem Res       Date:  1996-07       Impact factor: 3.996

3.  Characterization of glial trkB receptors: differential response to injury in the central and peripheral nervous systems.

Authors:  J Frisén; V M Verge; K Fried; M Risling; H Persson; J Trotter; T Hökfelt; D Lindholm
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-01       Impact factor: 11.205

4.  Septal cholinergic afferents regulate expression of brain-derived neurotrophic factor and beta-nerve growth factor mRNA in rat hippocampus.

Authors:  N Lindefors; P Ernfors; T Falkenberg; H Persson
Journal:  Exp Brain Res       Date:  1992       Impact factor: 1.972

Review 5.  Development of trophic interactions in the vertebrate peripheral nervous system.

Authors:  K S Vogel
Journal:  Mol Neurobiol       Date:  1993 Fall-Winter       Impact factor: 5.590

6.  Preparation of brain-derived neurotrophic factor- and neurotrophin-3-secreting Schwann cells by infection with a retroviral vector.

Authors:  S T Sayers; N Khan; Y Ahmed; R Shahid; T Khan
Journal:  J Mol Neurosci       Date:  1998-04       Impact factor: 3.444

7.  Coexpression of neurotrophins and their receptors in neurons of the central nervous system.

Authors:  Z Kokaia; J Bengzon; M Metsis; M Kokaia; H Persson; O Lindvall
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-15       Impact factor: 11.205

8.  Purification and characterization of biologically active recombinant human neurotrophin-3 produced by expression of a chimera gene in Chinese hamster ovary cells.

Authors:  M Iwane; T Watanabe; A Shintani; Y Kaisho; S Matsumoto; R Sasada; K Igarashi
Journal:  Appl Microbiol Biotechnol       Date:  1994-04       Impact factor: 4.813

9.  Expanded distribution of mRNA for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the rat brain after colchicine treatment.

Authors:  S Ceccatelli; P Ernfors; M J Villar; H Persson; T Hökfelt
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-15       Impact factor: 11.205

10.  Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma.

Authors:  O Lindvall; P Ernfors; J Bengzon; Z Kokaia; M L Smith; B K Siesjö; H Persson
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-15       Impact factor: 11.205
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