Literature DB >> 23650171

SatR is a repressor of fluoroquinolone efflux pump SatAB.

Jose Antonio Escudero1, Alvaro San Millan, Natalia Montero, Belen Gutierrez, Cristina Martinez Ovejero, Laura Carrilero, Bruno González-Zorn.   

Abstract

Streptococcus suis is an emerging zoonotic agent responsible for high-mortality outbreaks among the human population in China. In this species, the ABC transporter SatAB mediates fluoroquinolone resistance when overexpressed. Here, we describe and characterize satR, an open reading frame (ORF) encoding a MarR superfamily regulator that acts as a repressor of satAB. satR is cotranscribed with satAB, and its interruption entails the overexpression of the pump, leading to a clinically relevant increase in resistance to fluoroquinolones.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23650171      PMCID： PMC3697318          DOI： 10.1128/AAC.00515-13

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  Involvement of the putative ATP-dependent efflux proteins PatA and PatB in fluoroquinolone resistance of a multidrug-resistant mutant of Streptococcus pneumoniae.

Authors:  Estelle Marrer; Karen Schad; Andreas T Satoh; Malcolm G P Page; Maggie M Johnson; Laura J V Piddock
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

2.  Differences in virulence between two strains of Streptococcus suis type II after experimentally induced infection of newborn germ-free pigs.

Authors:  U Vecht; J P Arends; E J van der Molen; L A van Leengoed
Journal:  Am J Vet Res       Date:  1989-07       Impact factor: 1.156

3.  Characterization of antibiotic resistance in Streptococcus suis.

Authors:  Y Wasteson; S Høie; M C Roberts
Journal:  Vet Microbiol       Date:  1994-07       Impact factor: 3.293

4.  Antimicrobial resistance patterns and plasmid profiles of Streptococcus suis isolates.

Authors:  M Cantin; J Harel; R Higgins; M Gottschalk
Journal:  J Vet Diagn Invest       Date:  1992-04       Impact factor: 1.279

5.  A 10-year survey of antimicrobial susceptibility of streptococcus suis isolates from swine in Japan.

Authors:  Y Kataoka; T Yoshida; T Sawada
Journal:  J Vet Med Sci       Date:  2000-10       Impact factor: 1.267

6.  Antimicrobial susceptibility of clinical strains of Streptococcus suis isolated from pigs in Spain.

Authors:  Ana I Vela; Miguel A Moreno; José A Cebolla; Sergio González; María V Latre; Lucas Domínguez; José F Fernández-Garayzábal
Journal:  Vet Microbiol       Date:  2004-12-19       Impact factor: 3.293

7.  High-efficiency transformation and gene inactivation in Streptococcus suis type 2.

Authors:  H E Smith; H J Wisselink; U Vecht; A L Gielkens; M A Smits
Journal:  Microbiology       Date:  1995-01       Impact factor: 2.777

8.  In vitro antimicrobial susceptibility of Streptococcus suis strains isolated from clinically healthy sows in China.

Authors:  Chunping Zhang; Yibao Ning; Zhongqiu Zhang; Li Song; Huishen Qiu; Heyi Gao
Journal:  Vet Microbiol       Date:  2008-05-21       Impact factor: 3.293

9.  Trends in the resistance to antimicrobial agents of Streptococcus suis isolates from Denmark and Sweden.

Authors:  F M Aarestrup; S R Rasmussen; K Artursson; N E Jensen
Journal:  Vet Microbiol       Date:  1998-08-28       Impact factor: 3.293

Review 10.  Ligand-responsive transcriptional regulation by members of the MarR family of winged helix proteins.

Authors:  Steven P Wilkinson; Anne Grove
Journal:  Curr Issues Mol Biol       Date:  2006-01       Impact factor: 2.081
View more
  3 in total

1.  The Bacillus subtilis tyrZ gene encodes a highly selective tyrosyl-tRNA synthetase and is regulated by a MarR regulator and T box riboswitch.

Authors:  Rebecca N Williams-Wagner; Frank J Grundy; Medha Raina; Michael Ibba; Tina M Henkin
Journal:  J Bacteriol       Date:  2015-03-02       Impact factor: 3.490

2.  Upregulation of the PatAB Transporter Confers Fluoroquinolone Resistance to Streptococcus pseudopneumoniae.

Authors:  María Alvarado; Antonio J Martín-Galiano; María J Ferrándiz; Ángel Zaballos; Adela G de la Campa
Journal:  Front Microbiol       Date:  2017-10-26       Impact factor: 5.640

3.  Role of the Two-Component System CiaRH in the Regulation of Efflux Pump SatAB and Its Correlation with Fluoroquinolone Susceptibility.

Authors:  Xia Yang; Wei Peng; Ningning Wang; Beibei Dou; Fengming Yang; Huanchun Chen; Fangyan Yuan; Weicheng Bei
Journal:  Microbiol Spectr       Date:  2022-05-31
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.