Literature DB >> 23650159

Transition metal-α-amino acid complexes with antibiotic activity against Mycobacterium spp.

George W Karpin1, Joseph S Merola, Joseph O Falkinham.   

Abstract

Synthetic iridium-, rhodium-, and ruthenium-amino acid complexes with hydrophobic l-amino acids have antibiotic activity against Mycobacterium spp., including Mycobacterium bovis BCG and the rapidly growing species Mycobacterium abscessus and Mycobacterium chelonae. Concentrations of transition metal-amino acid complexes demonstrating hemolysis or cytotoxicity were 10- to 25-fold higher than were the MICs.

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Year:  2013        PMID： 23650159      PMCID： PMC3697346          DOI： 10.1128/AAC.00452-13

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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