Literature DB >> 23650096

Systematic investigation of parameters affecting the performance of an agitated filter-dryer.

Ekneet Kaur Sahni1, Robin H Bogner, Bodhisattwa Chaudhuri.   

Abstract

A systematic experimental investigation of contact drying operation was carried out in an agitated Charles Thompson filter-dryer. In this study, the effect of process parameters (wall temperature, impeller speed, fill level) on the drying performance in the filter-dryer is quantified as a function of bed temperature and solvent concentration. In addition, the impact of drying conditions on the particle size distribution was also examined. It was found that in the range of parameters investigated, drying rate increased with wall temperature and reduced bed depth. The effect of impeller speed was variable where favorable drying conditions were strongly dependent on the particle properties. Moreover, decrease in the particle size was evident with an increase in impeller speed and decrease in the bed depth due to increased collision frequency and reduction in the fill volume both leading to particle attrition respectively. Besides, the average wall to solid heat transfer coefficient is also estimated for variable operating conditions.
Copyright © 2013 Wiley Periodicals, Inc.

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Year:  2013        PMID: 23650096     DOI: 10.1002/jps.23572

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN: 0022-3549            Impact factor:   3.534


  1 in total

1.  A Novel Computational Approach Coupled with Machine Learning to Predict the Extent of Agglomeration in Particulate Processes.

Authors:  Kushal Sinha; Eric Murphy; Prashant Kumar; Kirsten A Springer; Raimundo Ho; Nandkishor K Nere
Journal:  AAPS PharmSciTech       Date:  2021-12-13       Impact factor: 3.246

  1 in total

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