Literature DB >> 23649962

Recent advances in the study of enzyme promiscuity in the tautomerase superfamily.

Bert-Jan Baas1, Ellen Zandvoort, Edzard M Geertsema, Gerrit J Poelarends.   

Abstract

Catalytic promiscuity and evolution: Many enzymes exhibit catalytic promiscuity--the ability to catalyze reactions other than their biologically relevant one. These reactions can serve as starting points for both natural and laboratory evolution of new enzymatic functions. Recent advances in the study of enzyme promiscuity in the tautomerase superfamily are discussed.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2013        PMID： 23649962     DOI： 10.1002/cbic.201300098

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  10 in total

1.  Evolution of a Catalytic Mechanism.

Authors:  Alissa Rauwerdink; Mark Lunzer; Titu Devamani; Bryan Jones; Joanna Mooney; Zhi-Jun Zhang; Jian-He Xu; Romas J Kazlauskas; Antony M Dean
Journal:  Mol Biol Evol       Date:  2015-12-16       Impact factor: 16.240

2.  A mutational analysis of active site residues in trans-3-chloroacrylic acid dehalogenase.

Authors:  Gerrit J Poelarends; Hector Serrano; Jamison P Huddleston; William H Johnson; Christian P Whitman
Journal:  FEBS Lett       Date:  2013-07-10       Impact factor: 4.124

3.  Second-Shell Amino Acid R266 Helps Determine N-Succinylamino Acid Racemase Reaction Specificity in Promiscuous N-Succinylamino Acid Racemase/o-Succinylbenzoate Synthase Enzymes.

Authors:  Dat P Truong; Simon Rousseau; Benjamin W Machala; Jamison P Huddleston; Mingzhao Zhu; Kenneth G Hull; Daniel Romo; Frank M Raushel; James C Sacchettini; Margaret E Glasner
Journal:  Biochemistry       Date:  2021-11-30       Impact factor: 3.162

4.  Engineering a Promiscuous Tautomerase into a More Efficient Aldolase for Self-Condensations of Linear Aliphatic Aldehydes.

Authors:  Mehran Rahimi; Jan-Ytzen van der Meer; Edzard M Geertsema; Gerrit J Poelarends
Journal:  Chembiochem       Date:  2017-05-30       Impact factor: 3.164

5.  Specificity Effects of Amino Acid Substitutions in Promiscuous Hydrolases: Context-Dependence of Catalytic Residue Contributions to Local Fitness Landscapes in Nearby Sequence Space.

Authors:  Christopher D Bayer; Bert van Loo; Florian Hollfelder
Journal:  Chembiochem       Date:  2017-05-02       Impact factor: 3.164

6.  Demethionylation of Pro-1 variants of 4-oxalocrotonate tautomerase in Escherichia coli by co-expression with an engineered methionine aminopeptidase.

Authors:  Bert-Jan Baas; Ellen Zandvoort; Anna A Wasiel; Gerrit J Poelarends
Journal:  FEBS Open Bio       Date:  2014-07-09       Impact factor: 2.693

Review 7.  Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.

Authors:  Andrew Currin; Neil Swainston; Philip J Day; Douglas B Kell
Journal:  Chem Soc Rev       Date:  2015-03-07       Impact factor: 54.564

8.  Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases.

Authors:  Jan-Ytzen van der Meer; Harshwardhan Poddar; Bert-Jan Baas; Yufeng Miao; Mehran Rahimi; Andreas Kunzendorf; Ronald van Merkerk; Pieter G Tepper; Edzard M Geertsema; Andy-Mark W H Thunnissen; Wim J Quax; Gerrit J Poelarends
Journal:  Nat Commun       Date:  2016-03-08       Impact factor: 14.919

Review 9.  Promiscuity in the Enzymatic Catalysis of Phosphate and Sulfate Transfer.

Authors:  Anna Pabis; Fernanda Duarte; Shina C L Kamerlin
Journal:  Biochemistry       Date:  2016-05-26       Impact factor: 3.162

Review 10.  The Generation and Exploitation of Protein Mutability Landscapes for Enzyme Engineering.

Authors:  Jan-Ytzen van der Meer; Lieuwe Biewenga; Gerrit J Poelarends
Journal:  Chembiochem       Date:  2016-08-19       Impact factor: 3.164
  10 in total

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