Literature DB >> 2364996

Norepinephrine and serotonin increase the vasoconstrictor response of the perfused rat tail artery to changes in cytosolic Ca2+.

N Thorin-Trescases1, L Oster, J Atkinson, C Capdeville.   

Abstract

Vasoconstriction and changes in cytosolic free Ca2+ concentrations (fura 2 with dual wavelength excitation) were measured simultaneously in the perfused tail artery of the rat. Vasoconstrictors (norepinephrine and 5-HT) appear to modulate contraction not only by changing the cytosolic free Ca2+ concentration but also by modifying the sensitivity of the contractile proteins to Ca2+.

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Year:  1990        PMID： 2364996     DOI： 10.1016/0014-2999(90)90191-8

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  2 in total

Review 1.  Vascular calcium overload. Physiological and pharmacological consequences.

Authors:  J Atkinson
Journal:  Drugs       Date:  1992       Impact factor: 9.546

2.  Chronic treatment with the angiotensin I converting enzyme inhibitor, perindopril, protects in vitro carbachol-induced vasorelaxation in a rat model of vascular calcium overload.

Authors:  D Henrion; J M Chillon; C Capdeville-Atkinson; M Vinceneux-Feugier; J Atkinson
Journal:  Br J Pharmacol       Date:  1991-12       Impact factor: 8.739
  2 in total

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