| Literature DB >> 23649700 |
Naoko Kogata1, Marketa Zvelebil, Beatrice A Howard.
Abstract
We review the role of Neuregulin 3 (Nrg3) and Erbb receptor signalling in embryonic mammary gland development. Neuregulins are growth factors that bind and activate its cognate Erbb receptor tyrosine kinases, which form a signalling network with established roles in breast development and breast cancer. Studies have shown that Nrg3 expression profoundly impacts early stages of embryonic mammary development. Network analysis shows how Nrg/Erbb signals could integrate with other major regulators of embryonic mammary development to elicit the morphogenetic processes and cell fate decisions that occur as the mammary lineage is established.Entities:
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Year: 2013 PMID: 23649700 DOI: 10.1007/s10911-013-9286-4
Source DB: PubMed Journal: J Mammary Gland Biol Neoplasia ISSN: 1083-3021 Impact factor: 2.673