Literature DB >> 23649700

Neuregulin 3 and erbb signalling networks in embryonic mammary gland development.

Naoko Kogata1, Marketa Zvelebil, Beatrice A Howard.   

Abstract

We review the role of Neuregulin 3 (Nrg3) and Erbb receptor signalling in embryonic mammary gland development. Neuregulins are growth factors that bind and activate its cognate Erbb receptor tyrosine kinases, which form a signalling network with established roles in breast development and breast cancer. Studies have shown that Nrg3 expression profoundly impacts early stages of embryonic mammary development. Network analysis shows how Nrg/Erbb signals could integrate with other major regulators of embryonic mammary development to elicit the morphogenetic processes and cell fate decisions that occur as the mammary lineage is established.

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Year:  2013        PMID: 23649700     DOI: 10.1007/s10911-013-9286-4

Source DB:  PubMed          Journal:  J Mammary Gland Biol Neoplasia        ISSN: 1083-3021            Impact factor:   2.673


  28 in total

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9.  Transcriptome analysis of embryonic mammary cells reveals insights into mammary lineage establishment.

Authors:  Olivia Wansbury; Alan Mackay; Naoko Kogata; Costas Mitsopoulos; Howard Kendrick; Kathryn Davidson; Christiana Ruhrberg; Jorge S Reis-Filho; Matthew J Smalley; Marketa Zvelebil; Beatrice A Howard
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Review 6.  Prenatal morphogenesis of mammary glands in mouse and rabbit.

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