Ultrasonic evaluation of microwave-induced thermal lesions based on wavelet analysis of mean scatterer spacing.

The microwave ablation has become an important manner for tumor treatment. In this paper, we proposed a new method for evaluation of microwave-induced thermal lesions using the wavelet analysis of the mean scatterer spacing (MSS). First, the ultrasonic radiofrequency (RF) data of normal and coagulated porcine liver tissues was collected through the temperature-controlled water bath heating experiments. The convex array ultrasound probe with a center frequency of 3.5 MHz was used. Second, the wavelet analysis was used to compute the MSS of normal and coagulated porcine liver tissues, respectively. Finally, the microwave-induced thermal lesions were detected based on the differences in the MSS between normal tissues and thermal lesions. Eighteen cases of microwave ablation experiments and 20 cases of water bath heating experiments were conducted on fresh porcine liver samples. The MSS of normal porcine liver tissues was 1.15±0.12 mm, and the MSS of coagulated porcine liver tissues was 0.93±0.07 mm. Six cases of thermal lesions were compared between the MSS-detected area and the caliper-measured area, and the MSS-detected area had an error of (13.55±5.29) %. The experimental results indicated that the proposed method could be used in preliminary detection and evaluation of microwave-induced thermal lesions.