| Literature DB >> 23648181 |
Jian Ken Zhang1, An-Rong Li, Ming Yu, Yingcai Wang, Jiang Zhu, Frank Kayser, Julio C Medina, Karen Siegler, Marion Conn, Bei Shan, Mark P Grillo, John Eksterowicz, Peter Coward, Jiwen Jim Liu.
Abstract
We describe the discovery of a series of arylsulfonyl 3-(pyridin-2-yloxy)anilines as GPR119 agonists derived from compound 1. Replacement of the three methyl groups in 1 with metabolically stable moieties led to the identification of compound 34, a potent and efficacious GPR119 agonist with improved pharmacokinetic (PK) properties.Entities:
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Year: 2013 PMID： 23648181 DOI： 10.1016/j.bmcl.2013.04.014
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823