PURPOSE: To assess the accumulated dose and the toxicity after reirradiation for tumors in the lung using non-rigid registration. MATERIAL AND METHODS: Twenty patients with a tumor in the lung were reirradiated with or after stereotactic radiotherapy. The summed dose distribution was calculated using non-rigid registration. All doses were recalculated to an equivalent dose of 2 Gy per fraction (EQD2). The median follow-up time was 12 months (range 2-52). RESULTS: The median Dmax of the lung in the summed plans was 363 Gy3 (range 123-590). The median accumulated V20 of the lungs was 15.2%. Seven patients had in the heart and the trachea an accumulated dose ≥70 Gy3, with a median D(max) of the heart of 115 Gy3 and 89 Gy3 for the trachea. Eight patients had in the esophagus an accumulated dose ≥70 Gy3, with a median accumulated dose of 85 Gy3. No grade 3-5 toxicity was observed. CONCLUSION: Reirradiation of the lung with or after stereotactic radiotherapy is feasible to a median Dmax of 363 Gy3 to the lung, as low toxicity was observed.
PURPOSE: To assess the accumulated dose and the toxicity after reirradiation for tumors in the lung using non-rigid registration. MATERIAL AND METHODS: Twenty patients with a tumor in the lung were reirradiated with or after stereotactic radiotherapy. The summed dose distribution was calculated using non-rigid registration. All doses were recalculated to an equivalent dose of 2 Gy per fraction (EQD2). The median follow-up time was 12 months (range 2-52). RESULTS: The median Dmax of the lung in the summed plans was 363 Gy3 (range 123-590). The median accumulated V20 of the lungs was 15.2%. Seven patients had in the heart and the trachea an accumulated dose ≥70 Gy3, with a median D(max) of the heart of 115 Gy3 and 89 Gy3 for the trachea. Eight patients had in the esophagus an accumulated dose ≥70 Gy3, with a median accumulated dose of 85 Gy3. No grade 3-5 toxicity was observed. CONCLUSION: Reirradiation of the lung with or after stereotactic radiotherapy is feasible to a median Dmax of 363 Gy3 to the lung, as low toxicity was observed.
Authors: Jeremy M Kilburn; Jeffrey G Kuremsky; A William Blackstock; Michael T Munley; William T Kearns; William H Hinson; James F Lovato; Antonius A Miller; William J Petty; James J Urbanic Journal: Radiother Oncol Date: 2014-01-17 Impact factor: 6.280
Authors: William R Kennedy; Prashant Gabani; John Nikitas; Clifford G Robinson; Jeffrey D Bradley; Michael C Roach Journal: Radiother Oncol Date: 2019-08-31 Impact factor: 6.280
Authors: Brane Grambozov; Evelyn Nussdorfer; Julia Kaiser; Sabine Gerum; Gerd Fastner; Markus Stana; Christoph Gaisberger; Romana Wass; Michael Studnicka; Felix Sedlmayer; Franz Zehentmayr Journal: Curr Oncol Date: 2021-05-13 Impact factor: 3.677