Literature DB >> 23647106

Simple atmospheric hydrogen/deuterium exchange method for enumeration of labile hydrogens by electrospray ionization mass spectrometry.

Yury Kostyukevich1, Alexey Kononikhin, Igor Popov, Eugene Nikolaev.   

Abstract

A simple method for hydrogen/deuterium exchange in a standard electrospray (ESI) ionization source is presented. In this method, a D₂O droplet is placed between the ESI needle and the entrance of the mass spectrometer and thus saturation of the atmosphere with deuterated vapor in the ESI region is achieved. It was shown that full exchange of up to 23 labile acidic hydrogens with a minimal back exchange with the surrounding atmospheric water can be performed by this method.

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Year:  2013        PMID： 23647106     DOI： 10.1021/ac4006606

Source DB:  PubMed          Journal:  Anal Chem        ISSN： 0003-2700            Impact factor:   6.986


  9 in total

1.  Design and Validation of In-Source Atmospheric Pressure Photoionization Hydrogen/Deuterium Exchange Mass Spectrometry with Continuous Feeding of D2O.

Authors:  Thamina Acter; Seulgidaun Lee; Eunji Cho; Maeng-Joon Jung; Sunghwan Kim
Journal:  J Am Soc Mass Spectrom       Date:  2017-10-27       Impact factor: 3.109

2.  Twelve million resolving power on 4.7 T Fourier transform ion cyclotron resonance instrument with dynamically harmonized cell--observation of fine structure in peptide mass spectra.

Authors:  Igor A Popov; Konstantin Nagornov; Gleb N Vladimirov; Yury I Kostyukevich; Eugene N Nikolaev
Journal:  J Am Soc Mass Spectrom       Date:  2014-03-07       Impact factor: 3.109

3.  Electrospray Photochemical Oxidation of Proteins.

Authors:  Remilekun O Lawal; Fabrizio Donnarumma; Kermit K Murray
Journal:  J Am Soc Mass Spectrom       Date:  2019-09-05       Impact factor: 3.109

4.  Application of Atmospheric Pressure Photoionization H/D-exchange Mass Spectrometry for Speciation of Sulfur-containing Compounds.

Authors:  Thamina Acter; Donghwi Kim; Arif Ahmed; Ji-Hyoung Ha; Sunghwan Kim
Journal:  J Am Soc Mass Spectrom       Date:  2017-05-09       Impact factor: 3.109

5.  Optimization and Application of APCI Hydrogen-Deuterium Exchange Mass Spectrometry (HDX MS) for the Speciation of Nitrogen Compounds.

Authors:  Thamina Acter; Yunju Cho; Sungji Kim; Arif Ahmed; Byungjoo Kim; Sunghwan Kim
Journal:  J Am Soc Mass Spectrom       Date:  2015-06-27       Impact factor: 3.109

6.  Characterization of Electrospray Ionization (ESI) Parameters on In-ESI Hydrogen/Deuterium Exchange of Carbohydrate-Metal Ion Adducts.

Authors:  O Tara Liyanage; Matthew R Brantley; Emvia I Calixte; Touradj Solouki; Kevin L Shuford; Elyssia S Gallagher
Journal:  J Am Soc Mass Spectrom       Date:  2018-10-23       Impact factor: 3.109

7.  Mass Spectral Detection of Forward- and Reverse-Hydrogen/Deuterium Exchange Resulting from Residual Solvent Vapors in Electrospray Sources.

Authors:  H Jamie Kim; O Tara Liyanage; Marina R Mulenos; Elyssia S Gallagher
Journal:  J Am Soc Mass Spectrom       Date:  2018-07-11       Impact factor: 3.109

8.  CID fragmentation, H/D exchange and supermetallization of Barnase-Barstar complex.

Authors:  Yury Kostyukevich; Aleksej A Shulga; Alexey Kononikhin; Igor Popov; Eugene Nikolaev; Sergey Deyev
Journal:  Sci Rep       Date:  2017-07-21       Impact factor: 4.379

9.  Laser Ablation Electrospray Ionization Hydrogen/Deuterium Exchange Ambient Mass Spectrometry Imaging.

Authors:  Fred A M G van Geenen; Frank W Claassen; Maurice C R Franssen; Han Zuilhof; Michel W F Nielen
Journal:  J Am Soc Mass Spectrom       Date:  2020-01-08       Impact factor: 3.109
  9 in total

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