Literature DB >> 23647057

An on-chip, multichannel droplet sorter using standing surface acoustic waves.

Sixing Li1, Xiaoyun Ding, Feng Guo, Yuchao Chen, Michael Ian Lapsley, Sz-Chin Steven Lin, Lin Wang, J Philip McCoy, Craig E Cameron, Tony Jun Huang.   

Abstract

The emerging field of droplet microfluidics requires effective on-chip handling and sorting of droplets. In this work, we demonstrate a microfluidic device that is capable of sorting picoliter water-in-oil droplets into multiple outputs using standing surface acoustic waves (SSAW). This device integrates a single-layer microfluidic channel with interdigital transducers (IDTs) to achieve on-chip droplet generation and sorting. Within the SSAW field, water-in-oil droplets experience an acoustic radiation force and are pushed toward the acoustic pressure node. As a result, by tuning the frequency of the SSAW excitation, the position of the pressure nodes can be changed and droplets can be sorted to different outlets at rates up to 222 droplets s(-1). With its advantages in simplicity, controllability, versatility, noninvasiveness, and capability to be integrated with other on-chip components such as droplet manipulation and optical detection units, the technique presented here could be valuable for the development of droplet-based micro total analysis systems (μTAS).

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Year:  2013        PMID: 23647057      PMCID: PMC3988909          DOI: 10.1021/ac400548d

Source DB:  PubMed          Journal:  Anal Chem        ISSN: 0003-2700            Impact factor:   6.986


  57 in total

1.  Dynamic pattern formation in a vesicle-generating microfluidic device.

Authors:  T Thorsen; R W Roberts; F H Arnold; S R Quake
Journal:  Phys Rev Lett       Date:  2001-04-30       Impact factor: 9.161

2.  Microfluidic device for single-cell analysis.

Authors:  Aaron R Wheeler; William R Throndset; Rebecca J Whelan; Andrew M Leach; Richard N Zare; Yish Hann Liao; Kevin Farrell; Ian D Manger; Antoine Daridon
Journal:  Anal Chem       Date:  2003-07-15       Impact factor: 6.986

3.  On-chip free-flow magnetophoresis: continuous flow separation of magnetic particles and agglomerates.

Authors:  Nicole Pamme; Andreas Manz
Journal:  Anal Chem       Date:  2004-12-15       Impact factor: 6.986

4.  Surface acoustic wave concentration of particle and bioparticle suspensions.

Authors:  Haiyan Li; James R Friend; Leslie Y Yeo
Journal:  Biomed Microdevices       Date:  2007-10       Impact factor: 2.838

5.  Rapid production of protein-loaded biodegradable microparticles using surface acoustic waves.

Authors:  Mar Alvarez; Leslie Y Yeo; James R Friend; Milan Jamriska
Journal:  Biomicrofluidics       Date:  2009-01-21       Impact factor: 2.800

6.  Surface acoustic wave actuated cell sorting (SAWACS).

Authors:  T Franke; S Braunmüller; L Schmid; A Wixforth; D A Weitz
Journal:  Lab Chip       Date:  2010-01-12       Impact factor: 6.799

7.  Particle separation in microfluidics using a switching ultrasonic field.

Authors:  Yang Liu; Kian-Meng Lim
Journal:  Lab Chip       Date:  2011-08-08       Impact factor: 6.799

8.  Concurrent droplet charging and sorting by electrostatic actuation.

Authors:  Byungwook Ahn; Kangsun Lee; Romain Louge; Kwang W Oh
Journal:  Biomicrofluidics       Date:  2009-10-13       Impact factor: 2.800

9.  A droplet-based, optofluidic device for high-throughput, quantitative bioanalysis.

Authors:  Feng Guo; Michael Ian Lapsley; Ahmad Ahsan Nawaz; Yanhui Zhao; Sz-Chin Steven Lin; Yuchao Chen; Shikuan Yang; Xing-Zhong Zhao; Tony Jun Huang
Journal:  Anal Chem       Date:  2012-11-27       Impact factor: 6.986

10.  Droplet size based separation by deterministic lateral displacement-separating droplets by cell--induced shrinking.

Authors:  Haakan N Joensson; Mathias Uhlén; Helene Andersson Svahn
Journal:  Lab Chip       Date:  2011-02-14       Impact factor: 6.799

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  31 in total

1.  A spatiotemporally controllable chemical gradient generator via acoustically oscillating sharp-edge structures.

Authors:  Po-Hsun Huang; Chung Yu Chan; Peng Li; Nitesh Nama; Yuliang Xie; Cheng-Hsin Wei; Yuchao Chen; Daniel Ahmed; Tony Jun Huang
Journal:  Lab Chip       Date:  2015-09-04       Impact factor: 6.799

2.  Probing Cell Deformability via Acoustically Actuated Bubbles.

Authors:  Yuliang Xie; Nitesh Nama; Peng Li; Zhangming Mao; Po-Hsun Huang; Chenglong Zhao; Francesco Costanzo; Tony Jun Huang
Journal:  Small       Date:  2015-12-30       Impact factor: 13.281

3.  Standing surface acoustic wave (SSAW)-based microfluidic cytometer.

Authors:  Yuchao Chen; Ahmad Ahsan Nawaz; Yanhui Zhao; Po-Hsun Huang; J Phillip McCoy; Stewart J Levine; Lin Wang; Tony Jun Huang
Journal:  Lab Chip       Date:  2014-03-07       Impact factor: 6.799

Review 4.  Rare cell isolation and analysis in microfluidics.

Authors:  Yuchao Chen; Peng Li; Po-Hsun Huang; Yuliang Xie; John D Mai; Lin Wang; Nam-Trung Nguyen; Tony Jun Huang
Journal:  Lab Chip       Date:  2014-02-21       Impact factor: 6.799

5.  Enriching Nanoparticles via Acoustofluidics.

Authors:  Zhangming Mao; Peng Li; Mengxi Wu; Hunter Bachman; Nicolas Mesyngier; Xiasheng Guo; Sheng Liu; Francesco Costanzo; Tony Jun Huang
Journal:  ACS Nano       Date:  2017-01-09       Impact factor: 15.881

Review 6.  Technology advancement for integrative stem cell analyses.

Authors:  Yoon Jeong; Jonghoon Choi; Kwan Hyi Lee
Journal:  Tissue Eng Part B Rev       Date:  2014-07-03       Impact factor: 6.389

7.  Continuous enrichment of low-abundance cell samples using standing surface acoustic waves (SSAW).

Authors:  Yuchao Chen; Sixing Li; Yeyi Gu; Peng Li; Xiaoyun Ding; Lin Wang; J Philip McCoy; Stewart J Levine; Tony Jun Huang
Journal:  Lab Chip       Date:  2014-03-07       Impact factor: 6.799

8.  Particle separation by phase modulated surface acoustic waves.

Authors:  Gergely Simon; Marco A B Andrade; Julien Reboud; Jose Marques-Hueso; Marc P Y Desmulliez; Jonathan M Cooper; Mathis O Riehle; Anne L Bernassau
Journal:  Biomicrofluidics       Date:  2017-10-26       Impact factor: 2.800

9.  Experimental and numerical studies on standing surface acoustic wave microfluidics.

Authors:  Zhangming Mao; Yuliang Xie; Feng Guo; Liqiang Ren; Po-Hsun Huang; Yuchao Chen; Joseph Rufo; Francesco Costanzo; Tony Jun Huang
Journal:  Lab Chip       Date:  2016-02-07       Impact factor: 6.799

10.  A high-throughput acoustic cell sorter.

Authors:  Liqiang Ren; Yuchao Chen; Peng Li; Zhangming Mao; Po-Hsun Huang; Joseph Rufo; Feng Guo; Lin Wang; J Philip McCoy; Stewart J Levine; Tony Jun Huang
Journal:  Lab Chip       Date:  2015-10-07       Impact factor: 6.799

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