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Literature DB >> 23646347

A bioreducible linear poly(β-amino ester) for siRNA delivery.

Kristen L Kozielski¹, Stephany Y Tzeng, Jordan J Green.

Abstract

Described here is the synthesis and characterization of a novel, bioreducible linear poly(β-amino ester) designed to condense siRNA into nanoparticles and efficiently release it upon entering the cytoplasm. Delivery of siRNA using this polymer achieved near-complete knockdown of a fluorescent marker gene in primary human glioblastoma cells with no cytotoxicity.

Entities: Chemical

Mesh：

Substances：

Year: 2013 PMID： 23646347 PMCID： PMC3894248 DOI： 10.1039/c3cc40718g

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

18 in total

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5. Optimization of poly(amido amine)s as vectors for siRNA delivery.

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