AIM: To evaluate the feasibility of carbogen-challenge blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) for assessing the early response of liver tumors to chemoembolization in a rat hepatoma model. MATERIALS AND METHODS: In a 9.4-Tesla scanner, a multiple gradient-recalled echo sequence was utilized for R2* measurement at 11 and 13 days after tumor implantation, first during room air breathing and then with carbogen gas (95% O2/5% CO2) breathing, to calculate the percentage changes of R2* values [ΔR2*(%)]. Transarterial chemoembolization was conducted 12 days after tumor implantation. RESULTS: The ΔR2* value of the tumors was 10.61 ± 8.94% on pre-chemoembolization images and -0.16 ± 1.85% on post-chemoembolization images. There was a significant difference in the ΔR2* value of the tumors between pre-chemoembolization and post-chemoembolization BOLD MRI (p=0.013). CONCLUSION: Carbogen-challenge BOLD MRI can be a non-invasive and useful method for the evaluation of early response of liver tumors to chemoembolization.
AIM: To evaluate the feasibility of carbogen-challenge blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) for assessing the early response of liver tumors to chemoembolization in a rathepatoma model. MATERIALS AND METHODS: In a 9.4-Tesla scanner, a multiple gradient-recalled echo sequence was utilized for R2* measurement at 11 and 13 days after tumor implantation, first during room air breathing and then with carbogen gas (95% O2/5% CO2) breathing, to calculate the percentage changes of R2* values [ΔR2*(%)]. Transarterial chemoembolization was conducted 12 days after tumor implantation. RESULTS: The ΔR2* value of the tumors was 10.61 ± 8.94% on pre-chemoembolization images and -0.16 ± 1.85% on post-chemoembolization images. There was a significant difference in the ΔR2* value of the tumors between pre-chemoembolization and post-chemoembolization BOLD MRI (p=0.013). CONCLUSION:Carbogen-challenge BOLD MRI can be a non-invasive and useful method for the evaluation of early response of liver tumors to chemoembolization.
Authors: Terence P F Gade; Stephen J Hunt; Neil Harrison; Gregory J Nadolski; Charles Weber; Stephen Pickup; Emma E Furth; Mitchell D Schnall; Michael C Soulen; M Celeste Simon Journal: J Vasc Interv Radiol Date: 2015-04-08 Impact factor: 3.464
Authors: Long Jiang Zhang; Zhuoli Zhang; Jian Xu; Ning Jin; Song Luo; Andrew C Larson; Guang Ming Lu Journal: Oncol Lett Date: 2015-07-23 Impact factor: 2.967
Authors: Vincenza Granata; Roberta Grassi; Roberta Fusco; Andrea Belli; Carmen Cutolo; Silvia Pradella; Giulia Grazzini; Michelearcangelo La Porta; Maria Chiara Brunese; Federica De Muzio; Alessandro Ottaiano; Antonio Avallone; Francesco Izzo; Antonella Petrillo Journal: Infect Agent Cancer Date: 2021-07-19 Impact factor: 2.965