OBJECTIVE: To assess the 6-month efficacy of uvulopalatopharyngoplasty (UPPP) compared with expectancy in selected patients with obstructive sleep apnoea syndrome (OSAS). DESIGN: A prospective single-centre randomised controlled trial with two parallel arms stratified by Friedman stage and body mass index (BMI). PARTICIPANTS: 65 consecutive patients with moderate to severe OSAS (apnoea-hypopnoea index (AHI) ≥15 events/h sleep), BMI <36 kg/m(2), Epworth sleepiness scale ≥8, Friedman stage I or II. INTERVENTION: Surgical treatment with UPPP. The control group underwent UPPP after a delay of 6 months. OUTCOMES: Changes in AHI and other polysomnography parameters at baseline compared with the 6-month follow-up. RESULTS: All patients (32 in the intervention group and 33 in the control group) completed the trial. The mean (SD) AHI in the intervention group decreased significantly (p<0.001) by 60% from 53.3 (19.7) events/h to 21.1 (16.7) events/h . In the control group the mean AHI decreased by 11% from 52.6 (21.7) events/h to 46.8 (22.8) events/h, with a significant difference between the groups (p<0.001). The mean time in the supine position and the BMI were unchanged in both groups. Subgroup analyses for Friedman stage, BMI group and tonsil size all showed significant reductions in AHI in the intervention group compared with controls. There were no severe complications after surgery. CONCLUSIONS: This trial demonstrates the efficacy of UPPP in treating selected patients with OSAS with a mean reduction in AHI of 60% compared with 11% in controls, a highly significant and clinically relevant difference between the groups. TRIAL REGISTRATION NUMBER: NCT01659671.
RCT Entities:
OBJECTIVE: To assess the 6-month efficacy of uvulopalatopharyngoplasty (UPPP) compared with expectancy in selected patients with obstructive sleep apnoea syndrome (OSAS). DESIGN: A prospective single-centre randomised controlled trial with two parallel arms stratified by Friedman stage and body mass index (BMI). PARTICIPANTS: 65 consecutive patients with moderate to severe OSAS (apnoea-hypopnoea index (AHI) ≥15 events/h sleep), BMI <36 kg/m(2), Epworth sleepiness scale ≥8, Friedman stage I or II. INTERVENTION: Surgical treatment with UPPP. The control group underwent UPPP after a delay of 6 months. OUTCOMES: Changes in AHI and other polysomnography parameters at baseline compared with the 6-month follow-up. RESULTS: All patients (32 in the intervention group and 33 in the control group) completed the trial. The mean (SD) AHI in the intervention group decreased significantly (p<0.001) by 60% from 53.3 (19.7) events/h to 21.1 (16.7) events/h . In the control group the mean AHI decreased by 11% from 52.6 (21.7) events/h to 46.8 (22.8) events/h, with a significant difference between the groups (p<0.001). The mean time in the supine position and the BMI were unchanged in both groups. Subgroup analyses for Friedman stage, BMI group and tonsil size all showed significant reductions in AHI in the intervention group compared with controls. There were no severe complications after surgery. CONCLUSIONS: This trial demonstrates the efficacy of UPPP in treating selected patients with OSAS with a mean reduction in AHI of 60% compared with 11% in controls, a highly significant and clinically relevant difference between the groups. TRIAL REGISTRATION NUMBER: NCT01659671.
Authors: Kenny Peter Pang; Guillermo Plaza; Peter M Baptista J; Carlos O'Connor Reina; Yiong Huak Chan; Kathleen A Pang; Edward B Pang; Cybil Mei Zhi Wang; Brian Rotenberg Journal: Eur Arch Otorhinolaryngol Date: 2018-05-25 Impact factor: 2.503
Authors: T Verse; A Dreher; C Heiser; M Herzog; J T Maurer; W Pirsig; K Rohde; N Rothmeier; A Sauter; A Steffen; S Wenzel; B A Stuck Journal: HNO Date: 2016-05 Impact factor: 1.284
Authors: T Verse; A Dreher; C Heiser; M Herzog; J T Maurer; W Pirsig; K Rohde; N Rothmeier; A Sauter; A Steffen; S Wenzel; B A Stuck Journal: Sleep Breath Date: 2016-05-14 Impact factor: 2.816
Authors: Stuart MacKay; A Simon Carney; Peter G Catcheside; Ching Li Chai-Coetzer; Michael Chia; Peter A Cistulli; John-Charles Hodge; Andrew Jones; Billingsley Kaambwa; Richard Lewis; Eng H Ooi; Alison J Pinczel; Nigel McArdle; Guy Rees; Bhajan Singh; Nicholas Stow; Edward M Weaver; Richard J Woodman; Charmaine M Woods; Aeneas Yeo; R Doug McEvoy Journal: JAMA Date: 2020-09-22 Impact factor: 56.272
Authors: Ulrich J Sommer; Clemens Heiser; Constanze Gahleitner; Raphael M Herr; Karl Hörmann; Joachim T Maurer; Boris A Stuck Journal: Dtsch Arztebl Int Date: 2016-01-11 Impact factor: 5.594