| Literature DB >> 23644218 |
Alessia Catalano1, Alessia Carocci, Ivana Defrenza, Marilena Muraglia, Antonio Carrieri, Françoise Van Bambeke, Antonio Rosato, Filomena Corbo, Carlo Franchini.
Abstract
A new series of 6-substituted 2-aminobenzothiazole derivatives were synthesized and screened in vitro as potential antimicrobials. Almost all the compounds showed antifungal activity. In particular, compounds 1n,o, designed on the basis of molecular modeling studies, were the best of the series, showing MIC values of 4-8 μg/mL against Candida albicans, Candida parapsilosis and Candida tropicalis. None of the two compounds did show any cytotoxicity effect on human THP-1 cells.Entities:
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Year: 2013 PMID： 23644218 DOI： 10.1016/j.ejmech.2013.03.064
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514