| Literature DB >> 23643984 |
Fabio Carletti1, Giuseppe Ferraro, Valerio Rizzo, Carla Cannizzaro, Pierangelo Sardo.
Abstract
Dimethyl sulfoxide (DMSO) is an amphipathic molecule widely used to solubilize water-insoluble compounds. In many studies it was reported that DMSO is capable of affecting several biological processes, thus resulting in a potential cause for the misinterpretation of experimental data. Recent papers showed that DMSO modified the brain bioelectric activity in animal models of epilepsy. In an in vivo model of temporal lobe epilepsy in the rat, we examined the effects of different doses (10%, 50% and 100%) of DMSO on the maximal dentate activation (MDA). The results show that DMSO induced a dose-dependent significant reduction of the electrically induced paroxysmal activity.Entities:
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Year: 2013 PMID： 23643984 DOI： 10.1016/j.neulet.2013.04.031
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046