Literature DB >> 23643644

Emerging roles of Cdk8 in cell cycle control.

Zsolt Szilagyi1, Claes M Gustafsson.   

Abstract

Cyclin dependent kinase 8 (Cdk8) is a component of Mediator, an evolutionary conserved multiprotein complex that regulates RNA polymerase II-dependent transcription. Cdk8 has been implicated as a regulator of multiple steps in cell cycle progression. We here discuss recent advances in our understanding of Cdk8 function and a possible role for Mediator as a hub for integrating transcription regulation with cell cycle progression.
Copyright © 2013 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Differentiation; Mediator; Mitosis; Protein stability; Stem cells; Wnt/β-catenin signaling

Mesh：

Substances：

Year:  2013        PMID： 23643644     DOI： 10.1016/j.bbagrm.2013.04.010

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  9 in total

1.  Mediator can regulate mitotic entry and direct periodic transcription in fission yeast.

Authors:  Gabor Banyai; Marcela Davila Lopez; Zsolt Szilagyi; Claes M Gustafsson
Journal:  Mol Cell Biol       Date:  2014-08-25       Impact factor: 4.272

2.  Aberrant expression of CDK8 regulates the malignant phenotype and associated with poor prognosis in human laryngeal squamous cell carcinoma.

Authors:  MingHua Li; XiaoDan Zhao; Ying Liu; Jun An; Hui Xiao; Chao Wang
Journal:  Eur Arch Otorhinolaryngol       Date:  2017-02-20       Impact factor: 2.503

Review 3.  Cyclins and cyclin-dependent kinases: from biology to tumorigenesis and therapeutic opportunities.

Authors:  Mitra Zabihi; Ramin Lotfi; Amir-Mohammad Yousefi; Davood Bashash
Journal:  J Cancer Res Clin Oncol       Date:  2022-07-04       Impact factor: 4.553

4.  Combining genetic perturbations and proteomics to examine kinase-phosphatase networks in Drosophila embryos.

Authors:  Richelle Sopko; Marianna Foos; Arunachalam Vinayagam; Bo Zhai; Richard Binari; Yanhui Hu; Sakara Randklev; Lizabeth A Perkins; Steven P Gygi; Norbert Perrimon
Journal:  Dev Cell       Date:  2014-10-02       Impact factor: 12.270

Review 5.  Targeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitors.

Authors:  Marion Peyressatre; Camille Prével; Morgan Pellerano; May C Morris
Journal:  Cancers (Basel)       Date:  2015-01-23       Impact factor: 6.639

6.  CDK8/19 inhibition induces premature G1/S transition and ATR-dependent cell death in prostate cancer cells.

Authors:  Akito Nakamura; Daisuke Nakata; Yuichi Kakoi; Mihoko Kunitomo; Saomi Murai; Shunsuke Ebara; Akito Hata; Takahito Hara
Journal:  Oncotarget       Date:  2018-02-06

Review 7.  Targeting cell cycle regulators in hematologic malignancies.

Authors:  Eiman Aleem; Robert J Arceci
Journal:  Front Cell Dev Biol       Date:  2015-04-09

8.  FgSsn3 kinase, a component of the mediator complex, is important for sexual reproduction and pathogenesis in Fusarium graminearum.

Authors:  Shulin Cao; Shijie Zhang; Chaofeng Hao; Huiquan Liu; Jin-Rong Xu; Qiaojun Jin
Journal:  Sci Rep       Date:  2016-03-02       Impact factor: 4.379

9.  Cyclin C influences the timing of mitosis in fission yeast.

Authors:  Gabor Banyai; Zsolt Szilagyi; Vera Baraznenok; Olga Khorosjutina; Claes M Gustafsson
Journal:  Mol Biol Cell       Date:  2017-05-17       Impact factor: 4.138
  9 in total

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