OBJECTIVE: To investigate the risk factors associated with neonatal hyperbilirubinemia in Malaysian neonates. METHODS: A prospective study was conducted to investigate the effects of glucose-6-phosphate dehydrogenase (G6PD) mutation, variant uridine diphosphate glucuronosyltransferase UGT1A1 gene and hepatic organic anion transporter protein (OATP2) gene on a group of neonates. Hyperbilirubinemia was defined as a total serum bilirubin level of ≥250 µmol/l. RESULTS: Of 318 neonates, 52 (16.4%) had hyperbilirubinemia. The incidence of G6PD mutation was 5.4% (15/280) among these infants. The incidence of G6PD mutation was significantly higher in the male neonates with hyperbilirubinemia (7.8%) when compared with the normal male neonates without hyperbilirubinemia (1.8%; p = 0.03). Logistic regression analysis showed that the significant risk factors for neonatal hyperbilirubinemia were Malay ethnicity [adjusted odds ratio (OR), 2.77; 95% confidence interval (CI): 1.31-5.86; p = 0.007] and G6PD mutation (adjusted OR, 3.29; 95% CI: 1.06-10.1820; p = 0.039). The gender, birth weight and gestation age of neonates, variant c.211G > A and variant of OATP2 gene were not significant. CONCLUSIONS: Neonates with Malay ethnicity and G6PD mutation were at risk for hyperbilirubinemia.
OBJECTIVE: To investigate the risk factors associated with neonatal hyperbilirubinemia in Malaysian neonates. METHODS: A prospective study was conducted to investigate the effects of glucose-6-phosphate dehydrogenase (G6PD) mutation, variant uridine diphosphate glucuronosyltransferase UGT1A1 gene and hepatic organic anion transporter protein (OATP2) gene on a group of neonates. Hyperbilirubinemia was defined as a total serum bilirubin level of ≥250 µmol/l. RESULTS: Of 318 neonates, 52 (16.4%) had hyperbilirubinemia. The incidence of G6PD mutation was 5.4% (15/280) among these infants. The incidence of G6PD mutation was significantly higher in the male neonates with hyperbilirubinemia (7.8%) when compared with the normal male neonates without hyperbilirubinemia (1.8%; p = 0.03). Logistic regression analysis showed that the significant risk factors for neonatal hyperbilirubinemia were Malay ethnicity [adjusted odds ratio (OR), 2.77; 95% confidence interval (CI): 1.31-5.86; p = 0.007] and G6PD mutation (adjusted OR, 3.29; 95% CI: 1.06-10.1820; p = 0.039). The gender, birth weight and gestation age of neonates, variant c.211G > A and variant of OATP2 gene were not significant. CONCLUSIONS: Neonates with Malay ethnicity and G6PD mutation were at risk for hyperbilirubinemia.
Authors: M F Alina; R Z Azma; J Norunaluwar; I Azlin; A J Darnina; F C Cheah; A R Noor-Farisah; A A Siti-Hawa; X R K Danny; Noor-Fadzilah Zulkifli; O Ainoon Journal: J Hum Genet Date: 2019-12-20 Impact factor: 3.172
Authors: Luis E Lozada; Cade M Nylund; Gregory H Gorman; Elizabeth Hisle-Gorman; Christine R Erdie-Lalena; Devon Kuehn Journal: Glob Pediatr Health Date: 2015-07-21