BACKGROUND: Chemokines play a pivotal role in immune regulation and response, and previous studies suggest an association between immune deficiency and non-Hodgkin lymphoma (NHL). METHODS: We evaluated the association between NHL and polymorphisms in 18 genes (CCL1, CCL2, CCL5, CCL7, CCL8, CCL11, CCL13, CCL18, CCL20, CCL24, CCL26, CCR1, CCR3, CCR4, CCR6, CCR7, CCR8, and CCR9) encoding for the CC chemokines using data from a population-based case-control study of NHL conducted in Connecticut women. RESULTS: CCR8 was associated with diffuse large B-cell lymphoma (DLBCL; P = 0.012), and CCL13 was associated with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL; P = 0.003) at gene level. After adjustment for multiple comparisons, none of the genes or single-nucleotide polymorphisms (SNP) were associated with risk of overall NHL or NHL subtypes. CONCLUSIONS: Our results suggest that the genes encoding for CC chemokines are not significantly associated with the risk of NHL, and further studies are needed to verify these findings. IMPACT: Our data indicate that CC chemokine genes were not associated with NHL risk.
BACKGROUND: Chemokines play a pivotal role in immune regulation and response, and previous studies suggest an association between immune deficiency and non-Hodgkin lymphoma (NHL). METHODS: We evaluated the association between NHL and polymorphisms in 18 genes (CCL1, CCL2, CCL5, CCL7, CCL8, CCL11, CCL13, CCL18, CCL20, CCL24, CCL26, CCR1, CCR3, CCR4, CCR6, CCR7, CCR8, and CCR9) encoding for the CC chemokines using data from a population-based case-control study of NHL conducted in Connecticut women. RESULTS:CCR8 was associated with diffuse large B-cell lymphoma (DLBCL; P = 0.012), and CCL13 was associated with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL; P = 0.003) at gene level. After adjustment for multiple comparisons, none of the genes or single-nucleotide polymorphisms (SNP) were associated with risk of overall NHL or NHL subtypes. CONCLUSIONS: Our results suggest that the genes encoding for CC chemokines are not significantly associated with the risk of NHL, and further studies are needed to verify these findings. IMPACT: Our data indicate that CC chemokine genes were not associated with NHL risk.
Authors: Wei Hu; Bryan A Bassig; Jun Xu; Tongzhang Zheng; Yawei Zhang; Sonja I Berndt; Theodore R Holford; H Dean Hosgood; Brian Leaderer; Meredith Yeager; Idan Menashe; Peter Boyle; Kaiyong Zou; Yong Zhu; Stephen Chanock; Qing Lan; Nathaniel Rothman Journal: Environ Mol Mutagen Date: 2012-10-11 Impact factor: 3.216
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Authors: Esther Teng; Khai Pang Leong; Hui Hua Li; Bernard Thong; Ee Tzun Koh; Pooi Ling Loi; Yi Zhao; Eng King Tan Journal: DNA Cell Biol Date: 2011-11-17 Impact factor: 3.311
Authors: Barbara Uhl; Katharina T Prochazka; Katrin Pansy; Kerstin Wenzl; Johanna Strobl; Claudia Baumgartner; Marta M Szmyra; James E Waha; Axel Wolf; Peter V Tomazic; Elisabeth Steinbauer; Maria Steinwender; Sabine Friedl; Marc Weniger; Ralf Küppers; Martin Pichler; Hildegard T Greinix; Georg Stary; Alan G Ramsay; Benedetta Apollonio; Julia Feichtinger; Christine Beham-Schmid; Peter Neumeister; Alexander J Deutsch Journal: Int J Mol Sci Date: 2022-07-17 Impact factor: 6.208