| Literature DB >> 23639546 |
Dalip Kumar1, K P Chandra Shekar, Bhupendra Mishra, Ryohsuke Kurihara, Maiko Ogura, Takeo Ito.
Abstract
A novel cationic porphyrin-quinoxaline conjugate 8 was prepared in good yield by the coupling of activated quinoxaline carboxylic acid 5 with an appropriate aminoporphyrin. The UV-vis spectra of conjugate 8 with the addition of ctDNA shows substantial hypochromicity (39%) and a red shift (12 nm) in the Soret band indicating intercalation and self stacking along the surface. The binding constant of conjugate 8 with ctDNA was determined to be 1.26×10(6) M(-1). The porphyrin-quinoxaline conjugate 8 displayed enhanced photocytotoxicity (IC50=0.06 μM) when compared to TMPyP against A549 cancer cells.Entities:
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Year: 2013 PMID： 23639546 DOI： 10.1016/j.bmcl.2013.03.126
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823