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Literature DB >> 23639035

Neuropeptide YY(2)R blockade in the central amygdala reduces anxiety-like behavior but not alcohol drinking in alcohol-dependent rats.

Marsida Kallupi¹, Leandro F Vendruscolo, Casey Y Carmichael, Olivier George, George F Koob, Nicholas W Gilpin.

Abstract

Electrophysiological data suggest a dual role of Y2 receptors (Y2 Rs) as autoreceptors regulating neuropeptide Y release and heteroceptors regulating gamma-aminobutyric acid release in the central amygdala (CeA). Here, we report that neither systemic (JNJ-31020028) nor intra-CeA (BIIE0246) Y2 R antagonism altered operant alcohol responding by alcohol-dependent or non-dependent rats. Conversely, BIIE0246 in the CeA reduced anxiety-like behavior in alcohol-dependent and alcohol-naïve rats. The finding that Y2 R antagonism reduces anxiety-like behavior but not alcohol drinking suggests that these two effects may occur via different functions of the Y2 R (e.g. autoreceptor versus heteroceptor function).

Entities: CellLine Chemical Disease Gene Species

Keywords: Alcohol dependence; Y2 receptor; anxiety; negative reinforcement; self-administration; vapor model

Mesh：

Substances：

Year: 2013 PMID： 23639035 PMCID： PMC3872251 DOI： 10.1111/adb.12059

Source DB: PubMed Journal: Addict Biol ISSN： 1355-6215 Impact factor: 4.280

10 in total

1. The central and basolateral amygdala are critical sites of neuropeptide Y/Y2 receptor-mediated regulation of anxiety and depression.

Authors: Ramon O Tasan; Ngoc Khoi Nguyen; Stefan Weger; Simone B Sartori; Nicolas Singewald; Regine Heilbronn; Herbert Herzog; Günther Sperk
Journal: J Neurosci Date: 2010-05-05 Impact factor: 6.167

Review 2. Neuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence.

Authors: Nicholas W Gilpin; Marisa Roberto
Journal: Neurosci Biobehav Rev Date: 2011-11-11 Impact factor: 8.989

3. Neuropeptide Y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence.

Authors: Nicholas W Gilpin; Kaushik Misra; Melissa A Herman; Maureen T Cruz; George F Koob; Marisa Roberto
Journal: Biol Psychiatry Date: 2011-04-03 Impact factor: 13.382

4. The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety.

Authors: Andrea Cippitelli; Amir H Rezvani; J Elliott Robinson; Lindsay Eisenberg; Edward D Levin; Pascal Bonaventure; S Timothy Motley; Timothy W Lovenberg; Markus Heilig; Annika Thorsell
Journal: Alcohol Date: 2010-12-10 Impact factor: 2.405

5. Suppression of ethanol self-administration by the neuropeptide Y (NPY) Y2 receptor antagonist BIIE0246: evidence for sensitization in rats with a history of dependence.

Authors: Roberto Rimondini; Annika Thorsell; Markus Heilig
Journal: Neurosci Lett Date: 2004-11-30 Impact factor: 3.046

6. Neuropeptide Y-Y2 receptors mediate anxiety in the amygdala.

Authors: Tammy J Sajdyk; Douglas A Schober; David L Smiley; Donald R Gehlert
Journal: Pharmacol Biochem Behav Date: 2002-03 Impact factor: 3.533

7. In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor.

Authors: James R Shoblock; Natalie Welty; Diane Nepomuceno; Brian Lord; Leah Aluisio; Ian Fraser; S Timothy Motley; Steve W Sutton; Kirsten Morton; Ruggero Galici; John R Atack; Lisa Dvorak; Devin M Swanson; Nicholas I Carruthers; Curt Dvorak; Timothy W Lovenberg; Pascal Bonaventure
Journal: Psychopharmacology (Berl) Date: 2009-12-02 Impact factor: 4.530

8. Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects.

Authors: M Heilig; S McLeod; M Brot; S C Heinrichs; F Menzaghi; G F Koob; K T Britton
Journal: Neuropsychopharmacology Date: 1993-06 Impact factor: 7.853

9. Autoreceptor-induced inhibition of neuropeptide Y release from PC-12 cells is mediated by Y2 receptors.

Authors: X Chen; D A DiMaggio; S P Han; T C Westfall
Journal: Am J Physiol Date: 1997-10

10. Neuropeptide Y inhibits potassium-stimulated glutamate release through Y2 receptors in rat hippocampal slices in vitro.

Authors: S Greber; C Schwarzer; G Sperk
Journal: Br J Pharmacol Date: 1994-11 Impact factor: 8.739

10 in total

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2. Voluntary induction and maintenance of alcohol dependence in rats using alcohol vapor self-administration.

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5. CRF₁ Receptor-Dependent Increases in Irritability-Like Behavior During Abstinence from Chronic Intermittent Ethanol Vapor Exposure.

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